Fe-S proteins in sensing and regulatory functions

In the past five to ten years, it has become increasingly apparent that the function of Fe-S clusters is not limited to electron transfer, a function implicit in their discovery. We now know that the vulnerability of these structures to oxidative destruction is used by nature in sensing O2, iron, an...

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Veröffentlicht in:	Current opinion in chemical biology 1999-04, Vol.3 (2), p.152-157
Hauptverfasser:	Beinert, Helmut, Kiley, Patricia J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - physiology Escherichia coli - metabolism Iron-Sulfur Proteins - physiology Oxidative Stress
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	In the past five to ten years, it has become increasingly apparent that the function of Fe-S clusters is not limited to electron transfer, a function implicit in their discovery. We now know that the vulnerability of these structures to oxidative destruction is used by nature in sensing O2, iron, and possibly also nitric oxide. Changes in the oxidation state of Fe-S clusters can also serve as a reversible switch.
ISSN:	1367-5931 1879-0402
DOI:	10.1016/S1367-5931(99)80027-1