The Effect of Tulobuterol Tape on Histamine-Induced Bronchoconstriction in Conscious Guinea Pigs: Long Duration of Action

The objective of the present study was to determine the action duration of tulobuterol tape within a 24-hr period in conscious guinea pigs. The bronchoconstriction induced by histamine-inhalation was significantly inhibited by tulobuterol tape in comparison with its placebo tape 8 and 12 hr after bi...

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Veröffentlicht in:	Japanese journal of pharmacology 1999, Vol.79(3), pp.401-402
Hauptverfasser:	Keiichi, Musoh, Kayoko, Kawamura, Isao, Miyake, Shino, Shimada, Tetsuo, Ohashi, Yuji, Iwanaga, Kouji, Morikawa, Hideo, Kato
Format:	Artikel
Sprache:	eng
Schlagworte:	A patch formulation Administration, Cutaneous Airway Resistance - drug effects Analysis of Variance Animals Bronchoconstriction - drug effects Bronchodilator Agents - pharmacology Consciousness Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Guinea Pigs Histamine - pharmacology Lung Volume Measurements Male Terbutaline - analogs & derivatives Terbutaline - pharmacology Time Factors Tulobuterol tape β2 stimulant
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Zusammenfassung:	The objective of the present study was to determine the action duration of tulobuterol tape within a 24-hr period in conscious guinea pigs. The bronchoconstriction induced by histamine-inhalation was significantly inhibited by tulobuterol tape in comparison with its placebo tape 8 and 12 hr after binding, and the inhibitory rate was 50±11% and 35±13%, respectively. Twenty-four hours after binding, the inhibitory effect of tulobuterol tape gradually diminished, but the inhibitory rate was maintained at 30±14%. These results suggest that tulobuterol tape has a long lasting bronchodilatory action.
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.79.401