Synthesis and biological studies of catechol ether type derivatives as potential phosphodiesterase (PDE) IV inhibitors

New series of catechol ether type derivatives 5, 6 have been synthesized and applied to biological tests. Even though it is a preliminary data, some of our target molecules show the promising result against PDE IV inhibition. SAR and biological studies with synthetic compounds will be discussed in d...

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Veröffentlicht in:	Archives of pharmacal research 1999-04, Vol.22 (2), p.202-207
Hauptverfasser:	Rhee, C K, Kim, J H, Suh, B C, Xiang, M X, Youn, Y S, Bang, W Y, Kim, E, Shin, J K, Lee, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors Animals Cyclic Nucleotide Phosphodiesterases, Type 4 Guinea Pigs Male Phosphodiesterase Inhibitors - chemical synthesis Phosphodiesterase Inhibitors - pharmacology Rats Rats, Sprague-Dawley Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	New series of catechol ether type derivatives 5, 6 have been synthesized and applied to biological tests. Even though it is a preliminary data, some of our target molecules show the promising result against PDE IV inhibition. SAR and biological studies with synthetic compounds will be discussed in detail.
ISSN:	0253-6269 1976-3786
DOI:	10.1007/BF02976547