Antioxidant systems in polymorphonuclear leucocytes of Type 2 diabetes mellitus

Summary Aims To examine the effect of Type 2 diabetes mellitus (DM) on enzymes of importance for oxygen‐dependent killing of microorganisms by leucocytes. Methods Twenty patients with Type 2 DM and 20 nondiabetic controls provided blood samples for analysis. Results The superoxide dismutase (SOD) ac...

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Veröffentlicht in:	Diabetic medicine 1999-01, Vol.16 (1), p.74-78
Hauptverfasser:	MUCHOVA, J, LIPTAKOVA, A, ORSZAGHOVA, Z, GARAIOVA, I, TISON, P, CARSKY, J, DURACKOVA, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult antioxidant systems Antioxidants - metabolism Biological and medical sciences Catalase - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - enzymology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glutathione Peroxidase - blood Glutathione Reductase - blood Humans Linear Models Male Medical sciences Middle Aged Neutrophils - enzymology PMN leucocytes Superoxide Dismutase - blood thiobarbituric acid reactive products Type 2 diabetes mellitus
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Zusammenfassung:	Summary Aims To examine the effect of Type 2 diabetes mellitus (DM) on enzymes of importance for oxygen‐dependent killing of microorganisms by leucocytes. Methods Twenty patients with Type 2 DM and 20 nondiabetic controls provided blood samples for analysis. Results The superoxide dismutase (SOD) activity was lower by 41% in polymorphonuclear leucocytes (PMNL) from patients with Type 2 DM than in controls (3.42 ± 0.32 U/mg of protein vs. 5.79 ± 0.71 U/mg of protein, P
ISSN:	0742-3071 1464-5491
DOI:	10.1046/j.1464-5491.1999.00015.x