Novel Brain-Specific 5-HT4 Receptor Splice Variants Show Marked Constitutive Activity: Role of the C-Terminal Intracellular Domain

We have cloned new 5-Hydroxytryptamine 4 (5-HT4) receptor splice variants from mouse (m5-HT4(e)R and m5-HT4(f)R), rat (r5-HT4(e)R), and human brain tissue (h5-HT4(e)R) which differ, as do the previously described 5-HT4 receptor variants, in the length and composition of their intracellular C termini...

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Veröffentlicht in:	Molecular pharmacology 1999-05, Vol.55 (5), p.910-920
Hauptverfasser:	Claeysen, Sylvie, Sebben, Michèle, Becamel, Carine, Bockaert, Joël, Dumuis, Aline
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Amino Acid Substitution Animals Brain - metabolism Cells, Cultured Cyclic AMP - biosynthesis Gene Deletion Humans Mice Molecular Sequence Data Mutation Protein Conformation Rats Receptors, Adrenergic, beta - genetics Receptors, Serotonin - chemistry Receptors, Serotonin - genetics Receptors, Serotonin, 5-HT4 Sequence Homology, Amino Acid Serotonin - metabolism
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Zusammenfassung:	We have cloned new 5-Hydroxytryptamine 4 (5-HT4) receptor splice variants from mouse (m5-HT4(e)R and m5-HT4(f)R), rat (r5-HT4(e)R), and human brain tissue (h5-HT4(e)R) which differ, as do the previously described 5-HT4 receptor variants, in the length and composition of their intracellular C termini after the common splicing site (L358). These new variants have a unique C-terminal sequence made of two PV repeats and are only expressed in brain tissue. All of the 5-HT4 receptor splice variants have a high constitutive activity when expressed at low and physiological densities (
ISSN:	0026-895X 1521-0111
DOI:	10.1016/S0026-895X(24)23188-6