IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R α and γ chains

Interleukin-7 has demonstrated potent enhancing effects on the growth and differentiation of several immature cell types, including thymocytes, and on survival of resting and antigen activated T cells. In this study, we evaluated the effects of IL-7 on post-thymic antigen-specific T cells from human...

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Veröffentlicht in:Journal of neuroimmunology 1999-04, Vol.96 (1), p.101-111
Hauptverfasser: Chou, Yuan K., Bourdette, Dennis N., Barnes, David, Finn, Thomas P., Murray, Susan, Unsicker, Laura, Robey, Ian, Whitham, Ruth H., Buenafe, Abigail C., Allegretta, Mark, Offner, Halina, Vandenbark, Arthur A.
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Sprache:eng
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Zusammenfassung:Interleukin-7 has demonstrated potent enhancing effects on the growth and differentiation of several immature cell types, including thymocytes, and on survival of resting and antigen activated T cells. In this study, we evaluated the effects of IL-7 on post-thymic antigen-specific T cells from human blood. IL-7 was found to enhance proliferation responses and IFN-γ secretion of myelin or recall Ag-specific Th1 cells through the selective up-regulation of the IL-2Rα and γ but not β chains in both an Ag-dependent and Ag-independent manner, but did not affect monocytes, B cells, or NK cells. These functions of IL-7 enhanced the detection of Th1 but not Th2 cell frequency by >2.5 fold, and promoted selection of Ag-specific Th1 cells by the limiting dilution method. Moreover, IL-7 pretreatment conferred increased resistance of CD4+ T cells to CD8+ cell lysis. These studies demonstrate that IL-7 promotes the growth and survival of circulating Ag-specific human Th1 cells through a mechanism that probably involves the γc common receptor for IL-2 family members that includes IL-7.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(99)00002-8