Multicenter randomized trial and a systematic overview of lidocaine in acute myocardial infarction

Multicenter randomized trial and a systematic overview of lidocaine in acute myocardial infarction

Background More than 20 randomized trials and 4 meta-analyses have been conducted on the use of prophylactic lidocaine in acute myocardial infarction (MI). The results suggest that lidocaine reduces ventricular fibrillation (VF) but increases mortality rates in acute MI. Methods and Results Patients...

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Veröffentlicht in:The American heart journal 1999-05, Vol.137 (5), p.792-798
Hauptverfasser: Sadowski, Zygmunt P., Alexander, John H., Skrabucha, Bogdan, Dyduszynski, Andrzej, Kuch, Jerzy, Nartowicz, Edmund, Swiatecka, Grazyna, Kong, David F., Granger, Christopher B.
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Arrhythmia Agents - administration & dosage
Anti-Arrhythmia Agents - therapeutic use
Antiarythmic agents
Biological and medical sciences
Cardiovascular system
Drug Therapy, Combination
Electrocardiography
Female
Fibrinolytic Agents - administration & dosage
Fibrinolytic Agents - therapeutic use
Follow-Up Studies
Heparin - administration & dosage
Heparin - therapeutic use
Hospital Mortality
Humans
Incidence
Infusions, Intravenous
Lidocaine - administration & dosage
Lidocaine - therapeutic use
Male
Medical sciences
Middle Aged
Myocardial Infarction - complications
Myocardial Infarction - drug therapy
Myocardial Infarction - mortality
Pharmacology. Drug treatments
Poland - epidemiology
Streptokinase - administration & dosage
Streptokinase - therapeutic use
Tachycardia, Ventricular - epidemiology
Tachycardia, Ventricular - etiology
Tachycardia, Ventricular - prevention & control
Thrombolytic Therapy
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Zusammenfassung:Background More than 20 randomized trials and 4 meta-analyses have been conducted on the use of prophylactic lidocaine in acute myocardial infarction (MI). The results suggest that lidocaine reduces ventricular fibrillation (VF) but increases mortality rates in acute MI. Methods and Results Patients with ST-elevation MI who were examined
ISSN:0002-8703
1097-6744
DOI:10.1016/S0002-8703(99)70401-1