Chiral Counteranion-Aided Asymmetric Hydrogenation of Acyclic Imines

Chiral Counteranion-Aided Asymmetric Hydrogenation of Acyclic Imines

When combined with a chiral phosphate counteranion, a chiral diamine-ligated Ir(III) catalyst displayed excellent enantioselectivities in the asymmetric hydrogenation of a wide range of acyclic imines, affording chiral amines in up to 99% ee.

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Veröffentlicht in:Journal of the American Chemical Society 2008-11, Vol.130 (44), p.14450-14451
Hauptverfasser: Li, Chaoqun, Wang, Chao, Villa-Marcos, Barbara, Xiao, Jianliang
Format: Artikel
Sprache:eng
Schlagworte:
Amines - chemical synthesis
Catalysis
Diamines - chemistry
Hydrogenation
Imines - chemistry
Iridium - chemistry
Organometallic Compounds - chemistry
Organophosphates - chemistry
Stereoisomerism
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Zusammenfassung:When combined with a chiral phosphate counteranion, a chiral diamine-ligated Ir(III) catalyst displayed excellent enantioselectivities in the asymmetric hydrogenation of a wide range of acyclic imines, affording chiral amines in up to 99% ee.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja807188s