Tenellic acids A-D: new bioactive diphenyl ether derivatives from the aquatic fungus Dendrospora tenella

Tenellic acids A-D (1-4) were isolated from cultures of the freshwater fungus Dendrospora tenella. The structures of these new diphenyl ether derivatives were determined primarily by analysis of NMR data. Compounds 1-4 display antimicrobial activity against Gram-positive bacteria.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1999-04, Vol.62 (4), p.580-583
Hauptverfasser:	Oh, H, Kwon, T.O, Gloer, J.B, Marvanova, L, Shearer, C.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology antibacterial properties Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology aquatic fungi Bacillus subtilis - drug effects Biological and medical sciences Candida albicans - drug effects chemical composition chemical structure Chemotherapic agents Dendrospora tenella derivatives Deuteromycotina diphenyl ether ethers Freshwater Fundamental and applied biological sciences. Psychology Gram-negative bacteria Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microbiology Mitosporic Fungi - chemistry nuclear magnetic resonance spectroscopy Phenyl Ethers - chemistry Phenyl Ethers - isolation & purification Phenyl Ethers - pharmacology secondary metabolites spectral analysis Spectrometry, Mass, Fast Atom Bombardment Staphylococcus aureus - drug effects tenellic acid tenellic acids
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Beschreibung
Zusammenfassung:	Tenellic acids A-D (1-4) were isolated from cultures of the freshwater fungus Dendrospora tenella. The structures of these new diphenyl ether derivatives were determined primarily by analysis of NMR data. Compounds 1-4 display antimicrobial activity against Gram-positive bacteria.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np980496m