Effects of Delayed Sample Processing and Freezing on Serum Concentrations of Selected Nutritional Indicators

Effects of Delayed Sample Processing and Freezing on Serum Concentrations of Selected Nutritional Indicators

Environmental conditions during sample processing, shipping, and storage are often suboptimal, particularly in less developed countries. We used samples from US volunteers to investigate the effects of delayed whole blood (WB) processing and delayed freezing of serum on selected nutritional indicato...

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Veröffentlicht in:Clinical chemistry (Baltimore, Md.) Md.), 2008-11, Vol.54 (11), p.1883-1891
Hauptverfasser: Drammeh, Bakary S, Schleicher, Rosemary L, Pfeiffer, Christine M, Jain, Ram B, Zhang, Mindy, Nguyen, Phuong Hong
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Blood Chemical Analysis
Carotenoids
Developed countries
Developing countries
Environmental conditions
Female
Freezing
Fundamental and applied biological sciences. Psychology
Humans
Investigative techniques, diagnostic techniques (general aspects)
LDCs
Male
Medical sciences
Nutrition
Nutritional Status
Population
Public health
Sample size
Specimen Handling
Vitamin C
Vitamin D
Vitamins
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Zusammenfassung:Environmental conditions during sample processing, shipping, and storage are often suboptimal, particularly in less developed countries. We used samples from US volunteers to investigate the effects of delayed whole blood (WB) processing and delayed freezing of serum on selected nutritional indicators. WB tubes (n = 35) were either stored at 32 degrees C for up to 3 days before serum separation or centrifuged within 2 h of collection; serum samples were stored at 11 degrees C for up to 14 days to simulate delayed shipping. We assessed analyte stability by comparing results with data from optimally prepared/stored serum samples (
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2008.108761