Protective effect of l-arginine on hypercholesterolemia-enhanced renal ischemic injury

The effects of hypercholesterolemia on ischemic renal failure were evaluated in rats subjected to 60 min of left renal artery clamping and contralateral nephrectomy. One group of rats (HC) was kept on a cholesterol-supplemented diet for 3 weeks before renal injury and compared to a group fed a regul...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Atherosclerosis 1999-04, Vol.143 (2), p.327-334
Hauptverfasser:	Campos, Silvia Bernardete, Ori, Maria, Dórea, Egı́dio Lima, Seguro, Antonio Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Acute Kidney Injury - etiology Acute Kidney Injury - pathology Acute renal failure Analysis of Variance Animals Arginine - pharmacology Biological and medical sciences Cells, Cultured - drug effects Cells, Cultured - metabolism Cholesterol, Dietary - adverse effects Disease Models, Animal Hypercholesterolemia Hypercholesterolemia - complications Hypercholesterolemia - metabolism Kidney - blood supply Kidney Function Tests Kidney Tubules, Collecting - cytology Kidney Tubules, Collecting - drug effects Kidney Tubules, Collecting - metabolism l-arginine L-Lactate Dehydrogenase - metabolism Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nitric oxide Nitric Oxide - analysis Nitric Oxide - biosynthesis Rats Rats, Wistar Reference Values Regional Blood Flow - drug effects Renovascular diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The effects of hypercholesterolemia on ischemic renal failure were evaluated in rats subjected to 60 min of left renal artery clamping and contralateral nephrectomy. One group of rats (HC) was kept on a cholesterol-supplemented diet for 3 weeks before renal injury and compared to a group fed a regular diet (ND). Two days after renal ischemia, inulin clearance ( C in, ml/min per 100 g BW) was lower in HC-rats (0.033±0.011) than in ND-rats (0.227±0.037; P
ISSN:	0021-9150 1879-1484
DOI:	10.1016/S0021-9150(98)00319-0