Multiple positive and negative regulators of signaling by the EGF-receptor

Signaling via the epidermal growth factor (EGF)-receptor family is subject to regulation and modulation by multiple ligands, effectors and negative regulators, as well as regulation by heterodimerization between family members and crosstalk between heterologous signaling pathways. Besides serving as...

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Veröffentlicht in:	Current opinion in cell biology 1999-04, Vol.11 (2), p.190-196
Hauptverfasser:	Moghal, Nadeem, Sternberg, Paul W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins Cell Adhesion Molecules - physiology Cell Membrane - metabolism Dimerization Epidermal Growth Factor - physiology Feedback Helminth Proteins - physiology Humans Ligands Models, Biological Neoplasm Proteins - physiology Phosphatidylinositol 3-Kinases - physiology Phosphorylation Protein Multimerization Protein Processing, Post-Translational Protein Tyrosine Phosphatases - metabolism Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - physiology Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	Signaling via the epidermal growth factor (EGF)-receptor family is subject to regulation and modulation by multiple ligands, effectors and negative regulators, as well as regulation by heterodimerization between family members and crosstalk between heterologous signaling pathways. Besides serving as a paradigm for receptor tyrosine kinases in general, this family is crucial for development and is often mutated or amplified in human tumors.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/S0955-0674(99)80025-8