Neurofibromatosis-Noonan syndrome and acute lymphoblastic leukemia : A report of two cases

Two boys with neurofibromatosis-Noonan syndrome in whom acute lymphoblastic leukemia (ALL) developed are described. Both patients demonstrated B-lineage leukemias with normal cytogenetics. They were treated with combination chemotherapy and remain in remission off therapy. Patients with neurofibroma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pediatric hematology/oncology 1999-03, Vol.21 (2), p.158-160
Hauptverfasser:	KLOPFENSTEIN, K. J, SOMMER, A, RUYMANN, F. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Child, Preschool Chromosomes, Human, Pair 12 - genetics Chromosomes, Human, Pair 17 - genetics Genes, Neurofibromatosis 1 Genes, ras Genetic Predisposition to Disease Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Neurofibromatoses - complications Neurofibromatoses - genetics Neurofibromin 1 Noonan Syndrome - complications Noonan Syndrome - genetics Phenotype Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology Proteins - physiology Remission Induction Risk
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Two boys with neurofibromatosis-Noonan syndrome in whom acute lymphoblastic leukemia (ALL) developed are described. Both patients demonstrated B-lineage leukemias with normal cytogenetics. They were treated with combination chemotherapy and remain in remission off therapy. Patients with neurofibromatosis-Noonan syndrome may be at increased risk for ALL.
ISSN:	1077-4114 1536-3678
DOI:	10.1097/00043426-199903000-00014