Biochemical alterations of uterine leiomyoma extracellular matrix in type IV Ehlers-Danlos syndrome

Collagens and glycosaminoglycans were assessed in 6 leiomyomas from otherwise healthy (“control”) patients and 1 leiomyoma from a patient with type IV Ehlers-Danlos syndrome. The type IV Ehlers-Danlos leiomyoma contained less type III collagen and dermatan sulfate than control leiomyomas. This might...

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Veröffentlicht in:	American journal of obstetrics and gynecology 1999-04, Vol.180 (4), p.1032-1034
Hauptverfasser:	Wegrowski, Yanusz, Bellon, Georges, Quéreux, Christian, Maquart, François-Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Collagen - metabolism collagens Ehlers-Danlos Syndrome - metabolism Extracellular Matrix - metabolism Female Female genital diseases glycosaminoglycans Glycosaminoglycans - metabolism Gynecology. Andrology. Obstetrics Humans Leiomyoma Leiomyoma - metabolism Medical sciences Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Tumors type IV Ehlers-Danlos syndrome Uterine Neoplasms - metabolism
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Zusammenfassung:	Collagens and glycosaminoglycans were assessed in 6 leiomyomas from otherwise healthy (“control”) patients and 1 leiomyoma from a patient with type IV Ehlers-Danlos syndrome. The type IV Ehlers-Danlos leiomyoma contained less type III collagen and dermatan sulfate than control leiomyomas. This might contribute to the formation of a defective collagen network in type IV Ehlers-Danlos syndrome. (Am J Obstet Gynecol 1999;180:1032-4.)
ISSN:	0002-9378 1097-6868
DOI:	10.1016/S0002-9378(99)70679-4