Gene targeting and somatic cell genetics: a rebirth or a coming of age?

A number of recent advances have significantly facilitated gene targeting in somatic cells. Gene targeting can now be performed with the same ease and efficiency in somatic cells as in murine embryonic stem cells. Rigorous genetic analyses can therefore be applied for the first time to the large num...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in genetics 1999-03, Vol.15 (3), p.88-90
Hauptverfasser:	Sedivy, John M, Dutriaux, Annie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cell culture Cell Line Classical genetics, quantitative genetics, hybrids DNA Fundamental and applied biological sciences. Psychology Gene Targeting Genetic Vectors Genetics of eukaryotes. Biological and molecular evolution Human Humans Hybrid Cells methodology Mice
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A number of recent advances have significantly facilitated gene targeting in somatic cells. Gene targeting can now be performed with the same ease and efficiency in somatic cells as in murine embryonic stem cells. Rigorous genetic analyses can therefore be applied for the first time to the large number of excellent human cell culture systems. These tools will be important in areas where rodent models do not adequately represent human biology.
ISSN:	0168-9525
DOI:	10.1016/S0168-9525(98)01689-8