High-intensity basal ganglia lesions on T1-weighted images in two toddlers with elevated blood manganese with portosystemic shunts

We report two toddlers with portosystemic shunts who had symmetrical high-signal globus pallidus lesions on T1- but not T2-weighted MRI, and measurement of whole blood manganese at 2 years of age. These cases suggest that portosystemic shunts can cause elevation of blood manganese and result in mang...

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Veröffentlicht in:	Neuroradiology 1999-03, Vol.41 (3), p.195-198
Hauptverfasser:	IHARA, K, HIJII, T, KUROMARU, R, ARIYOSHI, M, KIRA, R, FUKUSHIGE, J, HARA, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Brain Diseases - diagnosis Child, Preschool Diagnosis, Differential Female Galactosemias - complications Galactosemias - etiology Gastroenterology. Liver. Pancreas. Abdomen Globus Pallidus - chemistry Globus Pallidus - pathology Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Magnetic Resonance Imaging Male Malformations Manganese - blood Medical sciences Portal Vein - abnormalities
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Zusammenfassung:	We report two toddlers with portosystemic shunts who had symmetrical high-signal globus pallidus lesions on T1- but not T2-weighted MRI, and measurement of whole blood manganese at 2 years of age. These cases suggest that portosystemic shunts can cause elevation of blood manganese and result in manganese accumulation in the globus pallidus, causing high signal on T1-weighted images even in asymptomatic toddlers.
ISSN:	0028-3940 1432-1920
DOI:	10.1007/s002340050733