Myeloproliferative disorder by TKO

In this issue of Cell Stem Cell, Viatour et al. (2008) delete all three members of the retinoblastoma tumor suppressor gene family in hematopoietic stem cells, resulting in a myeloproliferative disorder. The disease was cell autonomous and resulted from alterations in the primitive hematopoietic cel...

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Veröffentlicht in:	Cell stem cell 2008-10, Vol.3 (4), p.361-362
1. Verfasser:	Adams, Gregor B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - metabolism Cell Differentiation Cell Lineage Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Mice Mice, Knockout Myeloproliferative Disorders - etiology Oligonucleotide Array Sequence Analysis Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism Retinoblastoma-Like Protein p107 - genetics Retinoblastoma-Like Protein p107 - metabolism Retinoblastoma-Like Protein p130 - genetics Retinoblastoma-Like Protein p130 - metabolism Signal Transduction
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Beschreibung
Zusammenfassung:	In this issue of Cell Stem Cell, Viatour et al. (2008) delete all three members of the retinoblastoma tumor suppressor gene family in hematopoietic stem cells, resulting in a myeloproliferative disorder. The disease was cell autonomous and resulted from alterations in the primitive hematopoietic cells.
ISSN:	1934-5909 1875-9777
DOI:	10.1016/j.stem.2008.09.008