Cerebrospinal fluid nitric oxide metabolites in painful diseases

To elucidate the involvement of NO in pain transmission in humans, we measured NO metabolites (nitrite/nitrate) in the CSF of patients with painful diseases using an NO analyzer based on the Griess method. The nitrite/nitrate levels in patients with degenerative lumbar disease (DLD), but not those w...

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Veröffentlicht in:Neuroreport 1999-02, Vol.10 (2), p.275-279
Hauptverfasser: Kimura, Shinji, Watanabe, Kenji, Yajiri, Yoichi, Motegi, Takashi, Masuya, Yuki, Shibuki, Katsuei, Uchiyama, Seiji, Homma, Takao, Takahashi, Hideaki E
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Sprache:eng
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Zusammenfassung:To elucidate the involvement of NO in pain transmission in humans, we measured NO metabolites (nitrite/nitrate) in the CSF of patients with painful diseases using an NO analyzer based on the Griess method. The nitrite/nitrate levels in patients with degenerative lumbar disease (DLD), but not those with fracture or appendicitis, were significantly higher than those in an age-matched control group. The duration of pain in the DLD group was much longer than that in the fracture or appendicitis group. The nitrite/nitrate levels in the middle-aged and elderly DLD patients depended on the duration of pain. These data probably suggest that the duration of pain is critical for the elevation in nitrite/nitrate levels.
ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-199902050-00013