Two New Cases of Papillary Renal Cell Carcinoma with t(X;1)(p11;q21) in Females

Two cases of papillary renal cell carcinoma (RCC) with a karyotype 46,X,t(X;1)(p11.2;q21) in two female patients aged 9 and 29 years are reported. These observations, and the review of the 17 reported cases with a translocation at band Xp11 confirm that this abnormality delineates a clinico-patholog...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1999-04, Vol.110 (1), p.54-56
Hauptverfasser:	Pérot, Christine, Bougaran, Joëlle, Boccon-Gibod, Liliane, Störkel, Stephan, Leverger, Guy, van den Akker, Jacqueline, Taillemite, Jean-Louis, Couturier, Jérôme
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma, Papillary - genetics Carcinoma, Renal Cell - genetics Child Chromosomes, Human, Pair 1 Female Humans Kidney Neoplasms - genetics Kidneys Medical sciences Nephrology. Urinary tract diseases Translocation, Genetic Tumors of the urinary system X Chromosome
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Zusammenfassung:	Two cases of papillary renal cell carcinoma (RCC) with a karyotype 46,X,t(X;1)(p11.2;q21) in two female patients aged 9 and 29 years are reported. These observations, and the review of the 17 reported cases with a translocation at band Xp11 confirm that this abnormality delineates a clinico-pathological entity within the classical papillary RCC, characterized by the early age of occurrence and, probably, distinct histological features. Including these two new female cases, the sex ratio in cases with t(X;1) appears similar to that observed in the other papillary RCC.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/S0165-4608(98)00181-2