Raloxifene effects on thyroid gland morphology in ovariectomized rats

We aimed to analyze the effects of raloxifene and estrogen on thyroid gland morphology of ovariectomized rats. Raloxifene treatment led to effects similar to those of estrogen on thyroid glands from ovariectomized rats, so that both were able to normalize the changes detected after ovariectomy.

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Bibliographische Detailangaben
Veröffentlicht in:	Fertility and sterility 2008-10, Vol.90 (4), p.1211-1214
Hauptverfasser:	de Araujo, Luiz Felipe Bittencourt, M.D, Grozovsky, Renata, Ph.D, de Campos Pinheiro, Mônica, Ph.D, de Carvalho, Jorge José, Ph.D, Vaisman, Mário, M.D, Carvalho, Denise P., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dose-Response Relationship, Drug Estrogens - administration & dosage Female Gynecology. Andrology. Obstetrics Internal Medicine Medical sciences Obstetrics and Gynecology Organ Size - drug effects Ovariectomy Raloxifene Hydrochloride - administration & dosage Rats Rats, Wistar Selective Estrogen Receptor Modulators - administration & dosage Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the genital tract and mammary gland Thyroid Gland - anatomy & histology Thyroid Gland - drug effects
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Beschreibung
Zusammenfassung:	We aimed to analyze the effects of raloxifene and estrogen on thyroid gland morphology of ovariectomized rats. Raloxifene treatment led to effects similar to those of estrogen on thyroid glands from ovariectomized rats, so that both were able to normalize the changes detected after ovariectomy.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2007.10.046