Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients

Philadelphia-negative (Ph-neg) essential thrombocythemia (ET), polycythemia vera (PV) and idiopathic myelofibrosis (IMF) form a syndrome of related chronic myeloproliferative disorders (MPD) characterized by expansion of one or more of the hematopoietic progenitors. Based on our previous finding of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Leukemia & lymphoma 1999-03, Vol.33 (1-2), p.77-82
Hauptverfasser: Aviram, A., Blickstein, D., Stark, P., Luboshitz, J., Bairey, O., Prokocimer, M., Shaklai, M.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 82
container_issue 1-2
container_start_page 77
container_title Leukemia & lymphoma
container_volume 33
creator Aviram, A.
Blickstein, D.
Stark, P.
Luboshitz, J.
Bairey, O.
Prokocimer, M.
Shaklai, M.
description Philadelphia-negative (Ph-neg) essential thrombocythemia (ET), polycythemia vera (PV) and idiopathic myelofibrosis (IMF) form a syndrome of related chronic myeloproliferative disorders (MPD) characterized by expansion of one or more of the hematopoietic progenitors. Based on our previous finding of BCR-ABL transcripts in bone marrow aspirates of 12/25 Ph-neg ET patients, we have expanded our study up to 40 patients. Here we describe the rational for performing this study and report 19 of 40 patients who have BCR-ABL transcripts in their BM, 11 of them carry b3a2 and 8 carry b2a2. The two groups, BCR-ABL positive and negative, were completely identical with regard to clinical characteristics and laboratory data. We also report preliminary results of our attempt to examine concordance or discordance of BCR-ABL expression in the peripheral blood and bone marrow of Ph-neg ET patients.
doi_str_mv 10.3109/10428199909093727
format Article
fullrecord <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_69679933</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69679933</sourcerecordid><originalsourceid>FETCH-LOGICAL-c433t-9014c4c0dd5e248e987e0e8c3b3da3fcce0b09d216c4c2852e320513a45ac7183</originalsourceid><addsrcrecordid>eNqFkUtv1DAURiMEoqXwA9ggr9gF_MrDgs3MqDykASoY1tEd56Zx5djB9lDm3-NougAhQF7Yss93dOWvKJ4y-kIwql4yKnnLlFI0L9Hw5l5xzihXJZdU3F_OkpcZkGfFoxhvKKWVqvnD4ozRfMm4OC9-fDHXzgxGg9NI_EDWm8_lar0luwAu6mDmFIlxZO0dkg8Qgr8lqzibAAnjwl-NxkKPdh4NlB_xGpL5juQyRnTJgCW7Mfhp7_UxjTgZIFcZyE_xcfFgABvxyd1-UXx9c7nbvCu3n96-36y2pZZCpFJRJrXUtO8r5LJF1TZIsdViL3oQg9ZI91T1nNWZ4m3FUXBaMQGyAt2wVlwUz0_eOfhvB4ypm0zUaC049IfY1apulBLivyBruKhbuRjZCdTBxxhw6OZgJgjHjtFu6aX7o5eceXYnP-wn7H9JnIrIwOsTYNzgwwS3Pti-S3C0Pgy5Cm3i4v67_9Vv8RHBplFDwO7GH4LLP_yP6X4CMu6uMw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17236848</pqid></control><display><type>article</type><title>Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients</title><source>Taylor &amp; Francis</source><source>MEDLINE</source><source>Taylor &amp; Francis Medical Library - CRKN</source><creator>Aviram, A. ; Blickstein, D. ; Stark, P. ; Luboshitz, J. ; Bairey, O. ; Prokocimer, M. ; Shaklai, M.</creator><creatorcontrib>Aviram, A. ; Blickstein, D. ; Stark, P. ; Luboshitz, J. ; Bairey, O. ; Prokocimer, M. ; Shaklai, M.</creatorcontrib><description>Philadelphia-negative (Ph-neg) essential thrombocythemia (ET), polycythemia vera (PV) and idiopathic myelofibrosis (IMF) form a syndrome of related chronic myeloproliferative disorders (MPD) characterized by expansion of one or more of the hematopoietic progenitors. Based on our previous finding of BCR-ABL transcripts in bone marrow aspirates of 12/25 Ph-neg ET patients, we have expanded our study up to 40 patients. Here we describe the rational for performing this study and report 19 of 40 patients who have BCR-ABL transcripts in their BM, 11 of them carry b3a2 and 8 carry b2a2. The two groups, BCR-ABL positive and negative, were completely identical with regard to clinical characteristics and laboratory data. We also report preliminary results of our attempt to examine concordance or discordance of BCR-ABL expression in the peripheral blood and bone marrow of Ph-neg ET patients.</description><identifier>ISSN: 1042-8194</identifier><identifier>EISSN: 1029-2403</identifier><identifier>DOI: 10.3109/10428199909093727</identifier><identifier>PMID: 10194123</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; BCR-ABL ; Bone Marrow - chemistry ; essential thrombocythemia ; Female ; Follow-Up Studies ; Genes, abl - genetics ; Humans ; Male ; Middle Aged ; myeloproliferative disorders ; Philadelphia Chromosome ; Polymerase Chain Reaction ; Thrombocythemia, Essential - genetics</subject><ispartof>Leukemia &amp; lymphoma, 1999-03, Vol.33 (1-2), p.77-82</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-9014c4c0dd5e248e987e0e8c3b3da3fcce0b09d216c4c2852e320513a45ac7183</citedby><cites>FETCH-LOGICAL-c433t-9014c4c0dd5e248e987e0e8c3b3da3fcce0b09d216c4c2852e320513a45ac7183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/10428199909093727$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/10428199909093727$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10194123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aviram, A.</creatorcontrib><creatorcontrib>Blickstein, D.</creatorcontrib><creatorcontrib>Stark, P.</creatorcontrib><creatorcontrib>Luboshitz, J.</creatorcontrib><creatorcontrib>Bairey, O.</creatorcontrib><creatorcontrib>Prokocimer, M.</creatorcontrib><creatorcontrib>Shaklai, M.</creatorcontrib><title>Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients</title><title>Leukemia &amp; lymphoma</title><addtitle>Leuk Lymphoma</addtitle><description>Philadelphia-negative (Ph-neg) essential thrombocythemia (ET), polycythemia vera (PV) and idiopathic myelofibrosis (IMF) form a syndrome of related chronic myeloproliferative disorders (MPD) characterized by expansion of one or more of the hematopoietic progenitors. Based on our previous finding of BCR-ABL transcripts in bone marrow aspirates of 12/25 Ph-neg ET patients, we have expanded our study up to 40 patients. Here we describe the rational for performing this study and report 19 of 40 patients who have BCR-ABL transcripts in their BM, 11 of them carry b3a2 and 8 carry b2a2. The two groups, BCR-ABL positive and negative, were completely identical with regard to clinical characteristics and laboratory data. We also report preliminary results of our attempt to examine concordance or discordance of BCR-ABL expression in the peripheral blood and bone marrow of Ph-neg ET patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>BCR-ABL</subject><subject>Bone Marrow - chemistry</subject><subject>essential thrombocythemia</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genes, abl - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>myeloproliferative disorders</subject><subject>Philadelphia Chromosome</subject><subject>Polymerase Chain Reaction</subject><subject>Thrombocythemia, Essential - genetics</subject><issn>1042-8194</issn><issn>1029-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAURiMEoqXwA9ggr9gF_MrDgs3MqDykASoY1tEd56Zx5djB9lDm3-NougAhQF7Yss93dOWvKJ4y-kIwql4yKnnLlFI0L9Hw5l5xzihXJZdU3F_OkpcZkGfFoxhvKKWVqvnD4ozRfMm4OC9-fDHXzgxGg9NI_EDWm8_lar0luwAu6mDmFIlxZO0dkg8Qgr8lqzibAAnjwl-NxkKPdh4NlB_xGpL5juQyRnTJgCW7Mfhp7_UxjTgZIFcZyE_xcfFgABvxyd1-UXx9c7nbvCu3n96-36y2pZZCpFJRJrXUtO8r5LJF1TZIsdViL3oQg9ZI91T1nNWZ4m3FUXBaMQGyAt2wVlwUz0_eOfhvB4ypm0zUaC049IfY1apulBLivyBruKhbuRjZCdTBxxhw6OZgJgjHjtFu6aX7o5eceXYnP-wn7H9JnIrIwOsTYNzgwwS3Pti-S3C0Pgy5Cm3i4v67_9Vv8RHBplFDwO7GH4LLP_yP6X4CMu6uMw</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Aviram, A.</creator><creator>Blickstein, D.</creator><creator>Stark, P.</creator><creator>Luboshitz, J.</creator><creator>Bairey, O.</creator><creator>Prokocimer, M.</creator><creator>Shaklai, M.</creator><general>Informa UK Ltd</general><general>Taylor &amp; Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients</title><author>Aviram, A. ; Blickstein, D. ; Stark, P. ; Luboshitz, J. ; Bairey, O. ; Prokocimer, M. ; Shaklai, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-9014c4c0dd5e248e987e0e8c3b3da3fcce0b09d216c4c2852e320513a45ac7183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>BCR-ABL</topic><topic>Bone Marrow - chemistry</topic><topic>essential thrombocythemia</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genes, abl - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>myeloproliferative disorders</topic><topic>Philadelphia Chromosome</topic><topic>Polymerase Chain Reaction</topic><topic>Thrombocythemia, Essential - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aviram, A.</creatorcontrib><creatorcontrib>Blickstein, D.</creatorcontrib><creatorcontrib>Stark, P.</creatorcontrib><creatorcontrib>Luboshitz, J.</creatorcontrib><creatorcontrib>Bairey, O.</creatorcontrib><creatorcontrib>Prokocimer, M.</creatorcontrib><creatorcontrib>Shaklai, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia &amp; lymphoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aviram, A.</au><au>Blickstein, D.</au><au>Stark, P.</au><au>Luboshitz, J.</au><au>Bairey, O.</au><au>Prokocimer, M.</au><au>Shaklai, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients</atitle><jtitle>Leukemia &amp; lymphoma</jtitle><addtitle>Leuk Lymphoma</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>33</volume><issue>1-2</issue><spage>77</spage><epage>82</epage><pages>77-82</pages><issn>1042-8194</issn><eissn>1029-2403</eissn><abstract>Philadelphia-negative (Ph-neg) essential thrombocythemia (ET), polycythemia vera (PV) and idiopathic myelofibrosis (IMF) form a syndrome of related chronic myeloproliferative disorders (MPD) characterized by expansion of one or more of the hematopoietic progenitors. Based on our previous finding of BCR-ABL transcripts in bone marrow aspirates of 12/25 Ph-neg ET patients, we have expanded our study up to 40 patients. Here we describe the rational for performing this study and report 19 of 40 patients who have BCR-ABL transcripts in their BM, 11 of them carry b3a2 and 8 carry b2a2. The two groups, BCR-ABL positive and negative, were completely identical with regard to clinical characteristics and laboratory data. We also report preliminary results of our attempt to examine concordance or discordance of BCR-ABL expression in the peripheral blood and bone marrow of Ph-neg ET patients.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>10194123</pmid><doi>10.3109/10428199909093727</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1042-8194
ispartof Leukemia & lymphoma, 1999-03, Vol.33 (1-2), p.77-82
issn 1042-8194
1029-2403
language eng
recordid cdi_proquest_miscellaneous_69679933
source Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN
subjects Adult
Aged
Aged, 80 and over
BCR-ABL
Bone Marrow - chemistry
essential thrombocythemia
Female
Follow-Up Studies
Genes, abl - genetics
Humans
Male
Middle Aged
myeloproliferative disorders
Philadelphia Chromosome
Polymerase Chain Reaction
Thrombocythemia, Essential - genetics
title Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T09%3A33%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Significance%20of%20BCR-ABL%20Transcripts%20in%20Bone%20Marrow%20Aspirates%20of%20Philadelphia-Negative%20Essential%20Thrombocythemia%20Patients&rft.jtitle=Leukemia%20&%20lymphoma&rft.au=Aviram,%20A.&rft.date=1999-03-01&rft.volume=33&rft.issue=1-2&rft.spage=77&rft.epage=82&rft.pages=77-82&rft.issn=1042-8194&rft.eissn=1029-2403&rft_id=info:doi/10.3109/10428199909093727&rft_dat=%3Cproquest_infor%3E69679933%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17236848&rft_id=info:pmid/10194123&rfr_iscdi=true