Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients
Philadelphia-negative (Ph-neg) essential thrombocythemia (ET), polycythemia vera (PV) and idiopathic myelofibrosis (IMF) form a syndrome of related chronic myeloproliferative disorders (MPD) characterized by expansion of one or more of the hematopoietic progenitors. Based on our previous finding of...
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Veröffentlicht in: | Leukemia & lymphoma 1999-03, Vol.33 (1-2), p.77-82 |
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creator | Aviram, A. Blickstein, D. Stark, P. Luboshitz, J. Bairey, O. Prokocimer, M. Shaklai, M. |
description | Philadelphia-negative (Ph-neg) essential thrombocythemia (ET), polycythemia vera (PV) and idiopathic myelofibrosis (IMF) form a syndrome of related chronic myeloproliferative disorders (MPD) characterized by expansion of one or more of the hematopoietic progenitors. Based on our previous finding of BCR-ABL transcripts in bone marrow aspirates of 12/25 Ph-neg ET patients, we have expanded our study up to 40 patients. Here we describe the rational for performing this study and report 19 of 40 patients who have BCR-ABL transcripts in their BM, 11 of them carry b3a2 and 8 carry b2a2. The two groups, BCR-ABL positive and negative, were completely identical with regard to clinical characteristics and laboratory data. We also report preliminary results of our attempt to examine concordance or discordance of BCR-ABL expression in the peripheral blood and bone marrow of Ph-neg ET patients. |
doi_str_mv | 10.3109/10428199909093727 |
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Based on our previous finding of BCR-ABL transcripts in bone marrow aspirates of 12/25 Ph-neg ET patients, we have expanded our study up to 40 patients. Here we describe the rational for performing this study and report 19 of 40 patients who have BCR-ABL transcripts in their BM, 11 of them carry b3a2 and 8 carry b2a2. The two groups, BCR-ABL positive and negative, were completely identical with regard to clinical characteristics and laboratory data. We also report preliminary results of our attempt to examine concordance or discordance of BCR-ABL expression in the peripheral blood and bone marrow of Ph-neg ET patients.</description><identifier>ISSN: 1042-8194</identifier><identifier>EISSN: 1029-2403</identifier><identifier>DOI: 10.3109/10428199909093727</identifier><identifier>PMID: 10194123</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; BCR-ABL ; Bone Marrow - chemistry ; essential thrombocythemia ; Female ; Follow-Up Studies ; Genes, abl - genetics ; Humans ; Male ; Middle Aged ; myeloproliferative disorders ; Philadelphia Chromosome ; Polymerase Chain Reaction ; Thrombocythemia, Essential - genetics</subject><ispartof>Leukemia & lymphoma, 1999-03, Vol.33 (1-2), p.77-82</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-9014c4c0dd5e248e987e0e8c3b3da3fcce0b09d216c4c2852e320513a45ac7183</citedby><cites>FETCH-LOGICAL-c433t-9014c4c0dd5e248e987e0e8c3b3da3fcce0b09d216c4c2852e320513a45ac7183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/10428199909093727$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/10428199909093727$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10194123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aviram, A.</creatorcontrib><creatorcontrib>Blickstein, D.</creatorcontrib><creatorcontrib>Stark, P.</creatorcontrib><creatorcontrib>Luboshitz, J.</creatorcontrib><creatorcontrib>Bairey, O.</creatorcontrib><creatorcontrib>Prokocimer, M.</creatorcontrib><creatorcontrib>Shaklai, M.</creatorcontrib><title>Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients</title><title>Leukemia & lymphoma</title><addtitle>Leuk Lymphoma</addtitle><description>Philadelphia-negative (Ph-neg) essential thrombocythemia (ET), polycythemia vera (PV) and idiopathic myelofibrosis (IMF) form a syndrome of related chronic myeloproliferative disorders (MPD) characterized by expansion of one or more of the hematopoietic progenitors. Based on our previous finding of BCR-ABL transcripts in bone marrow aspirates of 12/25 Ph-neg ET patients, we have expanded our study up to 40 patients. Here we describe the rational for performing this study and report 19 of 40 patients who have BCR-ABL transcripts in their BM, 11 of them carry b3a2 and 8 carry b2a2. The two groups, BCR-ABL positive and negative, were completely identical with regard to clinical characteristics and laboratory data. We also report preliminary results of our attempt to examine concordance or discordance of BCR-ABL expression in the peripheral blood and bone marrow of Ph-neg ET patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>BCR-ABL</subject><subject>Bone Marrow - chemistry</subject><subject>essential thrombocythemia</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genes, abl - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>myeloproliferative disorders</subject><subject>Philadelphia Chromosome</subject><subject>Polymerase Chain Reaction</subject><subject>Thrombocythemia, Essential - genetics</subject><issn>1042-8194</issn><issn>1029-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAURiMEoqXwA9ggr9gF_MrDgs3MqDykASoY1tEd56Zx5djB9lDm3-NougAhQF7Yss93dOWvKJ4y-kIwql4yKnnLlFI0L9Hw5l5xzihXJZdU3F_OkpcZkGfFoxhvKKWVqvnD4ozRfMm4OC9-fDHXzgxGg9NI_EDWm8_lar0luwAu6mDmFIlxZO0dkg8Qgr8lqzibAAnjwl-NxkKPdh4NlB_xGpL5juQyRnTJgCW7Mfhp7_UxjTgZIFcZyE_xcfFgABvxyd1-UXx9c7nbvCu3n96-36y2pZZCpFJRJrXUtO8r5LJF1TZIsdViL3oQg9ZI91T1nNWZ4m3FUXBaMQGyAt2wVlwUz0_eOfhvB4ypm0zUaC049IfY1apulBLivyBruKhbuRjZCdTBxxhw6OZgJgjHjtFu6aX7o5eceXYnP-wn7H9JnIrIwOsTYNzgwwS3Pti-S3C0Pgy5Cm3i4v67_9Vv8RHBplFDwO7GH4LLP_yP6X4CMu6uMw</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Aviram, A.</creator><creator>Blickstein, D.</creator><creator>Stark, P.</creator><creator>Luboshitz, J.</creator><creator>Bairey, O.</creator><creator>Prokocimer, M.</creator><creator>Shaklai, M.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients</title><author>Aviram, A. ; Blickstein, D. ; Stark, P. ; Luboshitz, J. ; Bairey, O. ; Prokocimer, M. ; Shaklai, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-9014c4c0dd5e248e987e0e8c3b3da3fcce0b09d216c4c2852e320513a45ac7183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>BCR-ABL</topic><topic>Bone Marrow - chemistry</topic><topic>essential thrombocythemia</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genes, abl - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>myeloproliferative disorders</topic><topic>Philadelphia Chromosome</topic><topic>Polymerase Chain Reaction</topic><topic>Thrombocythemia, Essential - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aviram, A.</creatorcontrib><creatorcontrib>Blickstein, D.</creatorcontrib><creatorcontrib>Stark, P.</creatorcontrib><creatorcontrib>Luboshitz, J.</creatorcontrib><creatorcontrib>Bairey, O.</creatorcontrib><creatorcontrib>Prokocimer, M.</creatorcontrib><creatorcontrib>Shaklai, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia & lymphoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aviram, A.</au><au>Blickstein, D.</au><au>Stark, P.</au><au>Luboshitz, J.</au><au>Bairey, O.</au><au>Prokocimer, M.</au><au>Shaklai, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients</atitle><jtitle>Leukemia & lymphoma</jtitle><addtitle>Leuk Lymphoma</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>33</volume><issue>1-2</issue><spage>77</spage><epage>82</epage><pages>77-82</pages><issn>1042-8194</issn><eissn>1029-2403</eissn><abstract>Philadelphia-negative (Ph-neg) essential thrombocythemia (ET), polycythemia vera (PV) and idiopathic myelofibrosis (IMF) form a syndrome of related chronic myeloproliferative disorders (MPD) characterized by expansion of one or more of the hematopoietic progenitors. Based on our previous finding of BCR-ABL transcripts in bone marrow aspirates of 12/25 Ph-neg ET patients, we have expanded our study up to 40 patients. Here we describe the rational for performing this study and report 19 of 40 patients who have BCR-ABL transcripts in their BM, 11 of them carry b3a2 and 8 carry b2a2. The two groups, BCR-ABL positive and negative, were completely identical with regard to clinical characteristics and laboratory data. We also report preliminary results of our attempt to examine concordance or discordance of BCR-ABL expression in the peripheral blood and bone marrow of Ph-neg ET patients.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>10194123</pmid><doi>10.3109/10428199909093727</doi><tpages>6</tpages></addata></record> |
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subjects | Adult Aged Aged, 80 and over BCR-ABL Bone Marrow - chemistry essential thrombocythemia Female Follow-Up Studies Genes, abl - genetics Humans Male Middle Aged myeloproliferative disorders Philadelphia Chromosome Polymerase Chain Reaction Thrombocythemia, Essential - genetics |
title | Significance of BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients |
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