Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease

Forty‐eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication. Nineteen extracts showed inhibitory effects on HIV‐induced cytopathic effects (CPE) on MT‐4 cells. The extracts were further screened against HIV‐1 protease (PR) using an...

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Veröffentlicht in:	Phytotherapy research 1999-02, Vol.13 (1), p.31-36
Hauptverfasser:	Hussein, Ghazi, Miyashiro, Hirotsugu, Nakamura, Norio, Hattori, Masao, Kawahata, Takuya, Otake, Toru, Kakiuchi, Nobuko, Shimotohno, Kunitada
Format:	Artikel
Sprache:	eng
Schlagworte:	Acacia nilotica AIDS/HIV Anti-HIV Agents - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid cytopathic effect Euphorbia granulata General pharmacology HIV Protease - metabolism HIV Protease Inhibitors - pharmacology HIV-1 - drug effects HIV-1 protease Human immunodeficiency virus 1 Humans Maytenus senegalensis Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - analysis Phenols - pharmacology Plant Epidermis - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Spectrophotometry, Ultraviolet Sudan Tannins - analysis Tannins - pharmacology viral replication Virus Replication - drug effects
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Zusammenfassung:	Forty‐eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication. Nineteen extracts showed inhibitory effects on HIV‐induced cytopathic effects (CPE) on MT‐4 cells. The extracts were further screened against HIV‐1 protease (PR) using an HPLC assay method. Of the tested extracts, the methanol extracts of Acacia nilotica (bark and pods), Euphorbia granulata (leaves), Maytenus senegalensis (stem‐bark) and aqueous extracts of A. nilotica (pods) and M. senegalensis (stem‐bark) showed considerable inhibitory effects against HIV‐1 PR. Inhibitory principles were isolated from M. senegalensis and their activities were also discussed. Copyright © 1999 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/(SICI)1099-1573(199902)13:1<31::AID-PTR381>3.0.CO;2-C