The MELD-Na is an independent short- and long-term prognostic predictor for hepatocellular carcinoma: A prospective survey

Abstract Background and aim Serum sodium has been suggested to incorporate into the model for end-stage liver disease to enhance its prognostic ability for cirrhosis. A mathematical equation based on model for end-stage liver disease and sodium, known as “MELD-Na”, was developed for outcome predicti...

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Veröffentlicht in:Digestive and liver disease 2008-11, Vol.40 (11), p.882-889
Hauptverfasser: Huo, T.-I, Lin, H.-C, Hsia, C.-Y, Huang, Y.-H, Wu, J.-C, Chiang, J.-H, Chiou, Y.-Y, Lui, W.-Y, Lee, P.-C, Lee, S.-D
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Sprache:eng
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Zusammenfassung:Abstract Background and aim Serum sodium has been suggested to incorporate into the model for end-stage liver disease to enhance its prognostic ability for cirrhosis. A mathematical equation based on model for end-stage liver disease and sodium, known as “MELD-Na”, was developed for outcome prediction for cirrhosis. The severity of liver cirrhosis is a key component to predict survival in patients with hepatocellular carcinoma. This study investigated the prognostic role of MELD-Na for hepatocellular carcinoma. Patients and methods A total of 535 unselected hepatocellular carcinoma patients were prospectively enrolled to evaluate the performance of MELD-Na. Results The MELD-Na was better than model for end-stage liver disease in predicting 6-month mortality by comparing the area under receiver operating characteristic curve (0.782 vs. 0.761, p = 0.101). MELD-Na, but not model for end-stage liver disease, was an independent predictor associated with 6-month mortality in multivariate logistic regression analysis (odds ratio: 1.14, p = 0.001). In the survival analysis, MELD-Na also independently predicted mortality, with an additional risk of 4.3% per unit increment of the score ( p < 0.001). Patients with MELD-Na scores between 10 and 20 and scores >20 had 2.1-fold ( p < 0.001) and 7.5-fold ( p < 0.001) risk of mortality, respectively, compared to patients with a score
ISSN:1590-8658
1878-3562
DOI:10.1016/j.dld.2008.01.015