Dynamic reoptimization of a fed-batch fermentor
Traditionally, fed‐batch biochemical process optimization and control use complicated models and off‐line optimizers with no on‐line model adaptation and re‐optimization. This work demonstrates the applicability, effectiveness, and economic potential, of a simple phenomenological model for modeling,...
Gespeichert in:
| Veröffentlicht in: | Biotechnology and bioengineering 1999-04, Vol.63 (1), p.10-21 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 21 |
|---|---|
| container_issue | 1 |
| container_start_page | 10 |
| container_title | Biotechnology and bioengineering |
| container_volume | 63 |
| creator | Iyer, Mahesh S. Wiesner, Theodore F. Rhinehart, R. Russell |
| description | Traditionally, fed‐batch biochemical process optimization and control use complicated models and off‐line optimizers with no on‐line model adaptation and re‐optimization. This work demonstrates the applicability, effectiveness, and economic potential, of a simple phenomenological model for modeling, and a novel optimizer for on‐line re‐optimization and control of an aerobic fed‐batch fermentor. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 63: 10–21, 1999. |
| doi_str_mv | 10.1002/(SICI)1097-0290(19990405)63:1<10::AID-BIT2>3.0.CO;2-C |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69665918</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>383993</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4442-e093d51bde909989ebc20f1a2a59eb12214fe87e353df469d86163ccf78a656e3</originalsourceid><addsrcrecordid>eNqFkU9vEzEQxS0EoqHwFVAOCLWHTcf2rr1OC1K7LWVRRQ4EKnEZOV6vWNg_wd4Iwqevl4QUCaScPCM9v3kzP0JeUZhQAHZy9CHP8mMKSkbAFBxRpRTEkBwLPqVnFKbT8_wyusjn7DWfwCSbnbIoe0BGux8PyQgARMQTxQ7IE--_hlamQjwmB2GCUomUI3JyuW51U5mxs92yr5rql-6rrh135ViPS1tEC92bL6FyjW37zj0lj0pde_ts-x6Sj2-u5tnb6GZ2nWfnN5GJ45hFFhQvEroorAqTUmUXhkFJNdNJqCljNC5tKi1PeFHGQhWpoIIbU8pUi0RYfkhebnyXrvu-sr7HpvLG1rVubbfyKJQQiaLpXiGjXCmewl4hlYynCgTfrWRc572zJS5d1Wi3Rgo4sEEc2OBwaRwujX_YoOBIBxUGNjiwQY6A2QwZZsH3-TbAatHY4i_XDYwgeLEVaG90XTrdmsrf66QEKel9vh9Vbdf_hNuX7T_RfvfBN9r4Vr63P3e-2n1DIblM8Pb9NWbqnbi4_TzHT_wOzCLC_w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17238906</pqid></control><display><type>article</type><title>Dynamic reoptimization of a fed-batch fermentor</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Iyer, Mahesh S. ; Wiesner, Theodore F. ; Rhinehart, R. Russell</creator><creatorcontrib>Iyer, Mahesh S. ; Wiesner, Theodore F. ; Rhinehart, R. Russell</creatorcontrib><description>Traditionally, fed‐batch biochemical process optimization and control use complicated models and off‐line optimizers with no on‐line model adaptation and re‐optimization. This work demonstrates the applicability, effectiveness, and economic potential, of a simple phenomenological model for modeling, and a novel optimizer for on‐line re‐optimization and control of an aerobic fed‐batch fermentor. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 63: 10–21, 1999.</description><identifier>ISSN: 0006-3592</identifier><identifier>EISSN: 1097-0290</identifier><identifier>DOI: 10.1002/(SICI)1097-0290(19990405)63:1<10::AID-BIT2>3.0.CO;2-C</identifier><identifier>PMID: 10099577</identifier><identifier>CODEN: BIBIAU</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Antibodies, Monoclonal - biosynthesis ; Biological and medical sciences ; Bioreactors ; Biotechnology ; Biotechnology - instrumentation ; Biotechnology - methods ; Cell Culture Techniques - instrumentation ; Cell Culture Techniques - methods ; dynamic re-optimization ; fed-batch fermentor ; Fermentation ; Fundamental and applied biological sciences. Psychology ; General aspects ; Humans ; Hybridomas - cytology ; Kinetics ; Mathematical models ; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) ; Methods. Procedures. Technologies ; Microbial engineering. Fermentation and microbial culture technology ; model re-parametrization ; Models, Theoretical ; Optimization ; Process control ; process-model mismatch ; Reproducibility of Results</subject><ispartof>Biotechnology and bioengineering, 1999-04, Vol.63 (1), p.10-21</ispartof><rights>Copyright © 1999 John Wiley & Sons, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 John Wiley & Sons, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4442-e093d51bde909989ebc20f1a2a59eb12214fe87e353df469d86163ccf78a656e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0290%2819990405%2963%3A1%3C10%3A%3AAID-BIT2%3E3.0.CO%3B2-C$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0290%2819990405%2963%3A1%3C10%3A%3AAID-BIT2%3E3.0.CO%3B2-C$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1770771$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10099577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iyer, Mahesh S.</creatorcontrib><creatorcontrib>Wiesner, Theodore F.</creatorcontrib><creatorcontrib>Rhinehart, R. Russell</creatorcontrib><title>Dynamic reoptimization of a fed-batch fermentor</title><title>Biotechnology and bioengineering</title><addtitle>Biotechnol. Bioeng</addtitle><description>Traditionally, fed‐batch biochemical process optimization and control use complicated models and off‐line optimizers with no on‐line model adaptation and re‐optimization. This work demonstrates the applicability, effectiveness, and economic potential, of a simple phenomenological model for modeling, and a novel optimizer for on‐line re‐optimization and control of an aerobic fed‐batch fermentor. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 63: 10–21, 1999.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Bioreactors</subject><subject>Biotechnology</subject><subject>Biotechnology - instrumentation</subject><subject>Biotechnology - methods</subject><subject>Cell Culture Techniques - instrumentation</subject><subject>Cell Culture Techniques - methods</subject><subject>dynamic re-optimization</subject><subject>fed-batch fermentor</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hybridomas - cytology</subject><subject>Kinetics</subject><subject>Mathematical models</subject><subject>Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)</subject><subject>Methods. Procedures. Technologies</subject><subject>Microbial engineering. Fermentation and microbial culture technology</subject><subject>model re-parametrization</subject><subject>Models, Theoretical</subject><subject>Optimization</subject><subject>Process control</subject><subject>process-model mismatch</subject><subject>Reproducibility of Results</subject><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vEzEQxS0EoqHwFVAOCLWHTcf2rr1OC1K7LWVRRQ4EKnEZOV6vWNg_wd4Iwqevl4QUCaScPCM9v3kzP0JeUZhQAHZy9CHP8mMKSkbAFBxRpRTEkBwLPqVnFKbT8_wyusjn7DWfwCSbnbIoe0BGux8PyQgARMQTxQ7IE--_hlamQjwmB2GCUomUI3JyuW51U5mxs92yr5rql-6rrh135ViPS1tEC92bL6FyjW37zj0lj0pde_ts-x6Sj2-u5tnb6GZ2nWfnN5GJ45hFFhQvEroorAqTUmUXhkFJNdNJqCljNC5tKi1PeFHGQhWpoIIbU8pUi0RYfkhebnyXrvu-sr7HpvLG1rVubbfyKJQQiaLpXiGjXCmewl4hlYynCgTfrWRc572zJS5d1Wi3Rgo4sEEc2OBwaRwujX_YoOBIBxUGNjiwQY6A2QwZZsH3-TbAatHY4i_XDYwgeLEVaG90XTrdmsrf66QEKel9vh9Vbdf_hNuX7T_RfvfBN9r4Vr63P3e-2n1DIblM8Pb9NWbqnbi4_TzHT_wOzCLC_w</recordid><startdate>19990405</startdate><enddate>19990405</enddate><creator>Iyer, Mahesh S.</creator><creator>Wiesner, Theodore F.</creator><creator>Rhinehart, R. Russell</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990405</creationdate><title>Dynamic reoptimization of a fed-batch fermentor</title><author>Iyer, Mahesh S. ; Wiesner, Theodore F. ; Rhinehart, R. Russell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4442-e093d51bde909989ebc20f1a2a59eb12214fe87e353df469d86163ccf78a656e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Bioreactors</topic><topic>Biotechnology</topic><topic>Biotechnology - instrumentation</topic><topic>Biotechnology - methods</topic><topic>Cell Culture Techniques - instrumentation</topic><topic>Cell Culture Techniques - methods</topic><topic>dynamic re-optimization</topic><topic>fed-batch fermentor</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Hybridomas - cytology</topic><topic>Kinetics</topic><topic>Mathematical models</topic><topic>Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)</topic><topic>Methods. Procedures. Technologies</topic><topic>Microbial engineering. Fermentation and microbial culture technology</topic><topic>model re-parametrization</topic><topic>Models, Theoretical</topic><topic>Optimization</topic><topic>Process control</topic><topic>process-model mismatch</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iyer, Mahesh S.</creatorcontrib><creatorcontrib>Wiesner, Theodore F.</creatorcontrib><creatorcontrib>Rhinehart, R. Russell</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biotechnology and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iyer, Mahesh S.</au><au>Wiesner, Theodore F.</au><au>Rhinehart, R. Russell</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic reoptimization of a fed-batch fermentor</atitle><jtitle>Biotechnology and bioengineering</jtitle><addtitle>Biotechnol. Bioeng</addtitle><date>1999-04-05</date><risdate>1999</risdate><volume>63</volume><issue>1</issue><spage>10</spage><epage>21</epage><pages>10-21</pages><issn>0006-3592</issn><eissn>1097-0290</eissn><coden>BIBIAU</coden><abstract>Traditionally, fed‐batch biochemical process optimization and control use complicated models and off‐line optimizers with no on‐line model adaptation and re‐optimization. This work demonstrates the applicability, effectiveness, and economic potential, of a simple phenomenological model for modeling, and a novel optimizer for on‐line re‐optimization and control of an aerobic fed‐batch fermentor. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 63: 10–21, 1999.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10099577</pmid><doi>10.1002/(SICI)1097-0290(19990405)63:1<10::AID-BIT2>3.0.CO;2-C</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3592 |
| ispartof | Biotechnology and bioengineering, 1999-04, Vol.63 (1), p.10-21 |
| issn | 0006-3592 1097-0290 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69665918 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Antibodies, Monoclonal - biosynthesis Biological and medical sciences Bioreactors Biotechnology Biotechnology - instrumentation Biotechnology - methods Cell Culture Techniques - instrumentation Cell Culture Techniques - methods dynamic re-optimization fed-batch fermentor Fermentation Fundamental and applied biological sciences. Psychology General aspects Humans Hybridomas - cytology Kinetics Mathematical models Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology model re-parametrization Models, Theoretical Optimization Process control process-model mismatch Reproducibility of Results |
| title | Dynamic reoptimization of a fed-batch fermentor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T00%3A45%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dynamic%20reoptimization%20of%20a%20fed-batch%20fermentor&rft.jtitle=Biotechnology%20and%20bioengineering&rft.au=Iyer,%20Mahesh%20S.&rft.date=1999-04-05&rft.volume=63&rft.issue=1&rft.spage=10&rft.epage=21&rft.pages=10-21&rft.issn=0006-3592&rft.eissn=1097-0290&rft.coden=BIBIAU&rft_id=info:doi/10.1002/(SICI)1097-0290(19990405)63:1%3C10::AID-BIT2%3E3.0.CO;2-C&rft_dat=%3Cproquest_cross%3E383993%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17238906&rft_id=info:pmid/10099577&rfr_iscdi=true |