Dynamic reoptimization of a fed-batch fermentor

Traditionally, fed‐batch biochemical process optimization and control use complicated models and off‐line optimizers with no on‐line model adaptation and re‐optimization. This work demonstrates the applicability, effectiveness, and economic potential, of a simple phenomenological model for modeling, and a novel optimizer for on‐line re‐optimization and control of an aerobic fed‐batch fermentor. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 63: 10–21, 1999.