Sustained Hepatitis B e Antigen Seroconversion in Patients with Chronic Hepatitis B after Adefovir Dipivoxil Treatment: Analysis of Precore and Basal Core Promoter Mutants

Background. This study evaluated the persistence of hepatitis B e antigen (HBeAg) seroconversion (which is considered to be an important therapeutic end point) after adefovir dipivoxil treatment. Methods. Forty-five patients who experienced confirmed HBeAg seroconversion and had a serum hepatitis B...

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Veröffentlicht in:	Clinical infectious diseases 2008-11, Vol.47 (10), p.1305-1311
Hauptverfasser:	Wu, I-Chin, Shiffman, Mitchell L., Tong, Myron J., Marcellin, Patrick, Mondou, Elsa, Frederick, David, Lampart, Andrea Snow, Sorbel, Jeff, Rousseau, Franck, Chang, Ting-Tsung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - therapeutic use Adult Alanine Transaminase - blood Antigens Antivirals Articles and Commentaries Asian Continental Ancestry Group Chronic hepatitis Deoxyribonucleic acid DNA DNA Mutational Analysis DNA, Viral - blood Drug therapy Drugs Durability European Continental Ancestry Group Female Genetic mutation Hepatitis Hepatitis antigens Hepatitis B Hepatitis B e Antigens - blood Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Hepatocellular carcinoma Hepatology Humans Liver Longitudinal Studies Male Middle Aged Mutation Nucleotides Organophosphonates - therapeutic use Pharmacology Promoter Regions, Genetic Viremia
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Zusammenfassung:	Background. This study evaluated the persistence of hepatitis B e antigen (HBeAg) seroconversion (which is considered to be an important therapeutic end point) after adefovir dipivoxil treatment. Methods. Forty-five patients who experienced confirmed HBeAg seroconversion and had a serum hepatitis B virus DNA level
ISSN:	1058-4838 1537-6591
DOI:	10.1086/592570