Microfluidic Electroporative Flow Cytometry for Studying Single-Cell Biomechanics

Microfluidic Electroporative Flow Cytometry for Studying Single-Cell Biomechanics

Biomechanical properties of cells yield important information on the disease state of cells such as transformation and metastasis. Screening of cells based on their biomechanical properties provides rapid tools for label-free diagnosis and staging of cancers. However, existent single-cell techniques...

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Veröffentlicht in:Analytical chemistry (Washington) 2008-10, Vol.80 (20), p.7714-7719
Hauptverfasser: Bao, Ning, Zhan, Yihong, Lu, Chang
Format: Artikel
Sprache:eng
Schlagworte:
Analytical chemistry
Biological and medical sciences
Biomechanical Phenomena
Biomechanics
Cancer
Cell cultures. Hybridization. Fusion
Cell Line, Tumor
Cell Size
Cell Survival
Cells
Cells - cytology
Chemistry
Cytoskeleton
Electrochemical methods
Electroporation - methods
Exact sciences and technology
Flow cytometry
Flow Cytometry - methods
Fundamental and applied biological sciences. Psychology
General aspects
Humans
Microfluidic Analytical Techniques - methods
Molecular and cellular biology
Oncology
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Beschreibung
Zusammenfassung:Biomechanical properties of cells yield important information on the disease state of cells such as transformation and metastasis. Screening of cells based on their biomechanical properties provides rapid tools for label-free diagnosis and staging of cancers. However, existent single-cell techniques for measuring biomechanical properties suffer from low throughput (
ISSN:0003-2700
1520-6882
DOI:10.1021/ac801060t