Stereoselective synthesis of novel cyclopropyl analogues of known cysteine protease inhibitors

Efficient synthesis of two novel analogues of some known protease inhibitors, via the isosteric replacement of oxirane/aziridine moiety of the parent compounds by cyclopropane ring, is described. Graphic

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-02, Vol.9 (4), p.513-514
Hauptverfasser:	Ravi Kumar, Jalluri S., Roy, Subho, Datta, Apurba
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Analytical, structural and metabolic biochemistry Aziridines - chemistry Biological and medical sciences Chemistry cyclopropane Cysteine Proteinase Inhibitors - chemical synthesis Cysteine Proteinase Inhibitors - chemistry enzyme inhibitor Enzymes and enzyme inhibitors Ethylene Oxide - chemistry Exact sciences and technology Fundamental and applied biological sciences. Psychology Hydrolases isostere Organic chemistry Preparations and properties Stereoisomerism stereoselective Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Efficient synthesis of two novel analogues of some known protease inhibitors, via the isosteric replacement of oxirane/aziridine moiety of the parent compounds by cyclopropane ring, is described. Graphic
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00029-3