Silver-Promoted Domino Pd-Catalyzed Amination/Direct Arylation: Access to Polycyclic Heteroaromatics
Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald−Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition...
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| Veröffentlicht in: | Organic letters 2008-10, Vol.10 (20), p.4633-4636 |
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| container_end_page | 4636 |
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| container_issue | 20 |
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| container_title | Organic letters |
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| creator | Bryan, Christopher S Lautens, Mark |
| description | Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald−Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition of silver salts. |
| doi_str_mv | 10.1021/ol801932z |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2008-10, Vol.10 (20), p.4633-4636 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69654472 |
| source | MEDLINE; ACS Publications |
| subjects | Amination Catalysis Indoles - chemistry Molecular Structure Oxidation-Reduction Palladium - chemistry Polycyclic Compounds - chemistry Silver - chemistry |
| title | Silver-Promoted Domino Pd-Catalyzed Amination/Direct Arylation: Access to Polycyclic Heteroaromatics |
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