Silver-Promoted Domino Pd-Catalyzed Amination/Direct Arylation: Access to Polycyclic Heteroaromatics

Silver-Promoted Domino Pd-Catalyzed Amination/Direct Arylation: Access to Polycyclic Heteroaromatics

Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald−Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition...

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Veröffentlicht in:Organic letters 2008-10, Vol.10 (20), p.4633-4636
Hauptverfasser: Bryan, Christopher S, Lautens, Mark
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Catalysis
Indoles - chemistry
Molecular Structure
Oxidation-Reduction
Palladium - chemistry
Polycyclic Compounds - chemistry
Silver - chemistry
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Zusammenfassung:Novel tetracyclic and pentacyclic indole derivatives can be prepared from readily available gem-dibromovinyl substrates in a single step by means of an efficient Pd-catalyzed domino Buchwald−Hartwig amination/direct arylation reaction. Enhanced reactivity and selectivity are obtained by the addition of silver salts.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol801932z