Preproenkephalin mRNA and enkephalin levels in the adult Syrian hamster: the influence from glucocorticoids

Proenkephalin (Penk) gene structure in hamsters and humans are similar but they differ from rats. In this study hamster Penk gene expression was examined after hypophysectomy±glucocorticoid receptor blockade with RU 486 (mifepristone). In contrast to rats, basal Penk gene expression in hamster adren...

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Veröffentlicht in:	Brain research. Molecular brain research. 1999-03, Vol.66 (1), p.179-183
Hauptverfasser:	Jimenez, Rosa, Yoburn, Byron C, Calvano, Steve E, Franklin, Steven O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - chemistry Adrenal Glands - physiology Adrenal medulla Age Factors Animals Biological and medical sciences Brain Chemistry - drug effects Brain Chemistry - genetics Corpus Striatum - chemistry Corpus Striatum - physiology Cricetinae Enkephalin Enkephalins - genetics Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Gene Expression - physiology General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions Glucocorticoid Glucocorticoids - pharmacology Hamster Hormone Antagonists - pharmacology Hypophysectomy Male Mesocricetus Mifepristone (RU 486) Mifepristone - pharmacology Protein Precursors - genetics Rats RNA, Messenger - analysis Striatum Vertebrates: endocrinology
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Zusammenfassung:	Proenkephalin (Penk) gene structure in hamsters and humans are similar but they differ from rats. In this study hamster Penk gene expression was examined after hypophysectomy±glucocorticoid receptor blockade with RU 486 (mifepristone). In contrast to rats, basal Penk gene expression in hamster adrenals did not change after treatments that reduced both the influence from glucocorticoids and phenylethanolamine- N-methyltransferase mRNA levels. Meanwhile, striatal preproenkephalin mRNA levels increased under these conditions.
ISSN:	0169-328X 1872-6941
DOI:	10.1016/S0169-328X(99)00019-4