Minoxidil increases 17 β-hydroxysteroid dehydrogenase and 5 α-reductase activity of cultured human dermal papilla cells from balding scalp

Minoxidil is known to induce hair growth in male pattern baldness, for which development androgen plays a central role. We studied the effect of minoxidil on testosterone metabolism by cultured dermal papilla cells from balding or nonbalding scalp and dermal fibroblasts. In all three groups, 17 β-hy...

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Veröffentlicht in:	Journal of dermatological science 1999-02, Vol.19 (2), p.123-125
Hauptverfasser:	Sato, Toshihiro, Tadokoro, Taketsugu, Sonoda, Tadashige, Asada, Yuji, Itami, Satoshi, Takayasu, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	17 β-HSD 17-Hydroxysteroid Dehydrogenases - metabolism 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism Adolescent Adult Aged Alopecia - enzymology Alopecia - metabolism Androgen Dermal papilla cells Enzyme Activation - drug effects Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - metabolism Hair Follicle - drug effects Hair Follicle - enzymology Hair Follicle - metabolism Humans Male Middle Aged Minoxidil Minoxidil - pharmacology Scalp - cytology Scalp - drug effects Scalp - enzymology Skin - drug effects Skin - enzymology Skin - metabolism Testosterone - metabolism Vasodilator Agents - pharmacology
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Zusammenfassung:	Minoxidil is known to induce hair growth in male pattern baldness, for which development androgen plays a central role. We studied the effect of minoxidil on testosterone metabolism by cultured dermal papilla cells from balding or nonbalding scalp and dermal fibroblasts. In all three groups, 17 β-hydroxysteroid dehydrogenase activity was much higher than 5 α-reductase activity. Minoxidil increased 17 β-hydroxysteroid dehydrogenase activity by nearly 40% ( P
ISSN:	0923-1811 1873-569X
DOI:	10.1016/S0923-1811(98)00048-6