Regulation of capsular polysialic acid biosynthesis by temperature in Pasteurella haemolytica A2

The capsular polysaccharide of Pasteurella haemolytica A2 consists of a linear polymer of N-acetylneuraminic acid (Neu5Ac) with α(2–8) linkages. The production of this polymer is strictly regulated by the growth temperature and above 40°C no production is detected. Analysis of the enzymatic activiti...

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Veröffentlicht in:	FEBS letters 1999-02, Vol.445 (2), p.325-328
Hauptverfasser:	Barrallo, Sofia, Reglero, Angel, Revilla-Nuin, Beatriz, Martı́nez-Blanco, Honorina, Rodrı́guez-Aparicio, Leandro B, Ferrero, Miguel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Capsules - metabolism CMP-Neu5Ac, cytidine 5′-monophospho-N-acetylneuraminic acid CTP, cytidine 5′-triphosphate DTT, dithiothreitol ManNAc, N-acetyl-d-mannosamine Mannheimia haemolytica - growth & development Mannheimia haemolytica - metabolism N-Acylneuraminate Cytidylyltransferase - metabolism Neu5Ac or sialic acid, N-acetyl-d-neuraminic acid Oxo-Acid-Lyases - metabolism PA, polysialic acid Pasteurella haemolytica Polysialic acid biosynthesis Pyr, pyruvate Sialic Acids - biosynthesis Sialyltransferases - metabolism Temperature
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