LRRK2 R1628P increases risk of Parkinson’s disease: replication evidence

We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson’s disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1–5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), th...

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Veröffentlicht in:	Human genetics 2008-10, Vol.124 (3), p.287-288
Hauptverfasser:	Tan, E. K., Tan, Louis C., Lim, H. Q., Li, R., Tang, M., Yih, Yuen, Pavanni, R., Prakash, K. M., Fook-Chong, S., Zhao, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Biomedical and Life Sciences Biomedicine Case-Control Studies China Classical genetics, quantitative genetics, hybrids Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Fundamental and applied biological sciences. Psychology Gene Function Genetic Predisposition to Disease Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genotype Heterozygote Human Human Genetics Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Medical colleges Medical research Medical sciences Medical screening Medicine, Experimental Metabolic Diseases Middle Aged Molecular Medicine Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neurosciences Parkinson Disease - ethnology Parkinson Disease - genetics Parkinson's disease Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology Risk Short Report
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Zusammenfassung:	We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson’s disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1–5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), the heterozygous R1628P genotype was associated with an increased risk of PD compared to controls (OR 3.3, 95% CI 1.4– 7.9, P = 0.007). We provided an independent confirmation that the R1628P variant increases the risk of PD among Chinese.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/s00439-008-0544-2