The LMC delta opioid recognition pharmacophore: Comparison of SNC80 and oxymorphindole

A recognition pharmacophore for the delta opioid receptor was developed de novo. Through the use of the pharmacophore and a novel four-point recognition model, major differences were observed between oxymorphindole and SNC80. This work suggests that these two classes of delta selective opioids do no...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-02, Vol.9 (3), p.357-362
Hauptverfasser:	Coop, Andrew, Jacobson, Arthur E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - chemistry Analgesics - pharmacology Benzamides - chemistry Benzamides - pharmacology Biological and medical sciences Medical sciences Models, Molecular Molecular Structure Morpholines - chemistry Morpholines - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Piperazines - chemistry Piperazines - pharmacology Receptors, Opioid, delta - agonists
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Zusammenfassung:	A recognition pharmacophore for the delta opioid receptor was developed de novo. Through the use of the pharmacophore and a novel four-point recognition model, major differences were observed between oxymorphindole and SNC80. This work suggests that these two classes of delta selective opioids do not bind to the delta opioid receptor in the same orientation. Through the use of the LMC delta opioid recognition pharmacophore and a four point recognition model, major differences were seen between SNC80 and oxymorphindole
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00745-8