An international collaborative study on the INR calibration of freeze‐dried reference plasmas
A study was carried out to calibrate potential European Reference Plasmas for prothrombin time (PT) standardization. The International Normalized Ratio (INR) values of three freeze‐dried candidate plasmas (one pooled normal and two pools from anticoagulated patients) were determined in 20 laboratori...
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| Veröffentlicht in: | British journal of haematology 1999-03, Vol.104 (3), p.455-460 |
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| container_title | British journal of haematology |
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| creator | HUBBARD, ANTHONY R. MARGETTS, SARAH M. L. WELLER, LYNNE J. MACNAB, JO BARROWCLIFFE, TREVOR W. |
| description | A study was carried out to calibrate potential European Reference Plasmas for prothrombin time (PT) standardization. The International Normalized Ratio (INR) values of three freeze‐dried candidate plasmas (one pooled normal and two pools from anticoagulated patients) were determined in 20 laboratories using six thromboplastin reagents comprising three International Reference Thromboplastins (human, rabbit and bovine), two recombinant human reagents and one placental human reagent. Inter‐laboratory variability of INR estimation was low with geometric coefficients of variation (gcv) |
| doi_str_mv | 10.1046/j.1365-2141.1999.01225.x |
| format | Article |
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L. ; WELLER, LYNNE J. ; MACNAB, JO ; BARROWCLIFFE, TREVOR W.</creator><creatorcontrib>HUBBARD, ANTHONY R. ; MARGETTS, SARAH M. L. ; WELLER, LYNNE J. ; MACNAB, JO ; BARROWCLIFFE, TREVOR W.</creatorcontrib><description>A study was carried out to calibrate potential European Reference Plasmas for prothrombin time (PT) standardization. The International Normalized Ratio (INR) values of three freeze‐dried candidate plasmas (one pooled normal and two pools from anticoagulated patients) were determined in 20 laboratories using six thromboplastin reagents comprising three International Reference Thromboplastins (human, rabbit and bovine), two recombinant human reagents and one placental human reagent. Inter‐laboratory variability of INR estimation was low with geometric coefficients of variation (gcv) <10% except in one case. Significant differences in mean INR were found between the different thromboplastins with lowest INR values found with the bovine reagent. INR values from the International rabbit and human reagents differed by <6% and were combined to give proposed assigned INR values. Significant differences in INR estimates from four thromboplastins of human origin may indicate that single assigned INR values are not applicable for use with all thromboplastin reagents. Field trials to assess the validity of single assigned INR values in clinical practice are required.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.1999.01225.x</identifier><identifier>PMID: 10086778</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Science Ltd</publisher><subject>Animals ; Biological and medical sciences ; Blood coagulation ; Blood Coagulation Factors - analysis ; Calibration ; Cattle ; Hematology ; Humans ; International Normalized Ratio ; International Normalized Ratio - standards ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; oral anticoagulants ; Prothrombin Time ; Rabbits ; Reference Values ; Thromboplastin - analysis</subject><ispartof>British journal of haematology, 1999-03, Vol.104 (3), p.455-460</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. 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L.</creatorcontrib><creatorcontrib>WELLER, LYNNE J.</creatorcontrib><creatorcontrib>MACNAB, JO</creatorcontrib><creatorcontrib>BARROWCLIFFE, TREVOR W.</creatorcontrib><title>An international collaborative study on the INR calibration of freeze‐dried reference plasmas</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>A study was carried out to calibrate potential European Reference Plasmas for prothrombin time (PT) standardization. The International Normalized Ratio (INR) values of three freeze‐dried candidate plasmas (one pooled normal and two pools from anticoagulated patients) were determined in 20 laboratories using six thromboplastin reagents comprising three International Reference Thromboplastins (human, rabbit and bovine), two recombinant human reagents and one placental human reagent. Inter‐laboratory variability of INR estimation was low with geometric coefficients of variation (gcv) <10% except in one case. Significant differences in mean INR were found between the different thromboplastins with lowest INR values found with the bovine reagent. INR values from the International rabbit and human reagents differed by <6% and were combined to give proposed assigned INR values. Significant differences in INR estimates from four thromboplastins of human origin may indicate that single assigned INR values are not applicable for use with all thromboplastin reagents. Field trials to assess the validity of single assigned INR values in clinical practice are required.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood coagulation</subject><subject>Blood Coagulation Factors - analysis</subject><subject>Calibration</subject><subject>Cattle</subject><subject>Hematology</subject><subject>Humans</subject><subject>International Normalized Ratio</subject><subject>International Normalized Ratio - standards</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>oral anticoagulants</subject><subject>Prothrombin Time</subject><subject>Rabbits</subject><subject>Reference Values</subject><subject>Thromboplastin - analysis</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS1ERYfCKyALoe4SfOOf2AsWbVVoUQUSgrXlODcio0w82Al0WPEIPCNPgtMZUcSKlW35O9c-5xBCgZXAhHq5LoErWVQgoARjTMmgqmR5-4Cs_lw8JCvGWF1kgT4mj1NaMwacSXhEjoExrepar4g9G2k_ThhHN_VhdAP1YRhcE2I-f0Waprnd0TDS6TPS63cfqHdD38Q7mIaOdhHxO_768bONPbY0YocRR490O7i0cekJOerckPDpYT0hn15ffry4Km7ev7m-OLspvKhAFs77GpjmUles4UaAY5WUHAWTLXjuO1TCd543bW2c7yDDynChRS2dBlT8hJzu525j-DJjmuymTx6zlRHDnKwyiisFC_j8H3Ad5ux-SBaMVkJBZTKk95CPIaVsym5jv3FxZ4HZpQG7tkvQdgnaLg3YuwbsbZY-O8yfmw22fwn3kWfgxQFwKYfZRTf6Pt1zSmtWLf98tce-9QPu_vt9e_72atnx397woVs</recordid><startdate>199903</startdate><enddate>199903</enddate><creator>HUBBARD, ANTHONY R.</creator><creator>MARGETTS, SARAH M. L.</creator><creator>WELLER, LYNNE J.</creator><creator>MACNAB, JO</creator><creator>BARROWCLIFFE, TREVOR W.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199903</creationdate><title>An international collaborative study on the INR calibration of freeze‐dried reference plasmas</title><author>HUBBARD, ANTHONY R. ; MARGETTS, SARAH M. L. ; WELLER, LYNNE J. ; MACNAB, JO ; BARROWCLIFFE, TREVOR W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4215-acc710835820b3941a02553e405d1c3cfe64cfc3bd79acf171069348475a81e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood coagulation</topic><topic>Blood Coagulation Factors - analysis</topic><topic>Calibration</topic><topic>Cattle</topic><topic>Hematology</topic><topic>Humans</topic><topic>International Normalized Ratio</topic><topic>International Normalized Ratio - standards</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>oral anticoagulants</topic><topic>Prothrombin Time</topic><topic>Rabbits</topic><topic>Reference Values</topic><topic>Thromboplastin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HUBBARD, ANTHONY R.</creatorcontrib><creatorcontrib>MARGETTS, SARAH M. L.</creatorcontrib><creatorcontrib>WELLER, LYNNE J.</creatorcontrib><creatorcontrib>MACNAB, JO</creatorcontrib><creatorcontrib>BARROWCLIFFE, TREVOR W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HUBBARD, ANTHONY R.</au><au>MARGETTS, SARAH M. L.</au><au>WELLER, LYNNE J.</au><au>MACNAB, JO</au><au>BARROWCLIFFE, TREVOR W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An international collaborative study on the INR calibration of freeze‐dried reference plasmas</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>1999-03</date><risdate>1999</risdate><volume>104</volume><issue>3</issue><spage>455</spage><epage>460</epage><pages>455-460</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>A study was carried out to calibrate potential European Reference Plasmas for prothrombin time (PT) standardization. The International Normalized Ratio (INR) values of three freeze‐dried candidate plasmas (one pooled normal and two pools from anticoagulated patients) were determined in 20 laboratories using six thromboplastin reagents comprising three International Reference Thromboplastins (human, rabbit and bovine), two recombinant human reagents and one placental human reagent. Inter‐laboratory variability of INR estimation was low with geometric coefficients of variation (gcv) <10% except in one case. Significant differences in mean INR were found between the different thromboplastins with lowest INR values found with the bovine reagent. INR values from the International rabbit and human reagents differed by <6% and were combined to give proposed assigned INR values. Significant differences in INR estimates from four thromboplastins of human origin may indicate that single assigned INR values are not applicable for use with all thromboplastin reagents. Field trials to assess the validity of single assigned INR values in clinical practice are required.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Science Ltd</pub><pmid>10086778</pmid><doi>10.1046/j.1365-2141.1999.01225.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | British journal of haematology, 1999-03, Vol.104 (3), p.455-460 |
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| source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological and medical sciences Blood coagulation Blood Coagulation Factors - analysis Calibration Cattle Hematology Humans International Normalized Ratio International Normalized Ratio - standards Investigative techniques, diagnostic techniques (general aspects) Medical sciences oral anticoagulants Prothrombin Time Rabbits Reference Values Thromboplastin - analysis |
| title | An international collaborative study on the INR calibration of freeze‐dried reference plasmas |
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