An international collaborative study on the INR calibration of freeze‐dried reference plasmas

A study was carried out to calibrate potential European Reference Plasmas for prothrombin time (PT) standardization. The International Normalized Ratio (INR) values of three freeze‐dried candidate plasmas (one pooled normal and two pools from anticoagulated patients) were determined in 20 laboratori...

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Veröffentlicht in:	British journal of haematology 1999-03, Vol.104 (3), p.455-460
Hauptverfasser:	HUBBARD, ANTHONY R., MARGETTS, SARAH M. L., WELLER, LYNNE J., MACNAB, JO, BARROWCLIFFE, TREVOR W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood coagulation Blood Coagulation Factors - analysis Calibration Cattle Hematology Humans International Normalized Ratio International Normalized Ratio - standards Investigative techniques, diagnostic techniques (general aspects) Medical sciences oral anticoagulants Prothrombin Time Rabbits Reference Values Thromboplastin - analysis
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Beschreibung
Zusammenfassung:	A study was carried out to calibrate potential European Reference Plasmas for prothrombin time (PT) standardization. The International Normalized Ratio (INR) values of three freeze‐dried candidate plasmas (one pooled normal and two pools from anticoagulated patients) were determined in 20 laboratories using six thromboplastin reagents comprising three International Reference Thromboplastins (human, rabbit and bovine), two recombinant human reagents and one placental human reagent. Inter‐laboratory variability of INR estimation was low with geometric coefficients of variation (gcv)
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.1999.01225.x