Antiviral Tannins from Two Phyllanthus Species

Abstract: Seven ellagitannins isolated from PHYLLANTHUS MYRTIFOLIUS and P. URINARIA (Euphorbiaceae) have been shown, for the first time, to be active against Epstein-Barr virus DNA polymerase (EBV-DP) at the μM level. All these compounds have the same moiety of a corilagin, and differ from each othe...

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Veröffentlicht in:	Planta medica 1999-02, Vol.65 (1), p.043-046
Hauptverfasser:	Chen Liu, Karin C. S., Lin, Mei-Tsu, Lee, Shoei-Sheng, Chiou, Jwo-Farn, Ren, Shijun, Lien, Eric J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Biological and medical sciences Cell Line DNA Polymerase I - antagonists & inhibitors Euphorbiaceae - chemistry General pharmacology Herpesvirus 4, Human - drug effects Herpesvirus 4, Human - enzymology Humans Hydrolyzable Tannins Medical sciences Molecular Structure Original Paper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Spectrum Analysis Structure-Activity Relationship Tannins - chemistry Tannins - isolation & purification Tannins - pharmacology
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Zusammenfassung:	Abstract: Seven ellagitannins isolated from PHYLLANTHUS MYRTIFOLIUS and P. URINARIA (Euphorbiaceae) have been shown, for the first time, to be active against Epstein-Barr virus DNA polymerase (EBV-DP) at the μM level. All these compounds have the same moiety of a corilagin, and differ from each other by different substitutions at C-2 and C-4 of the glucose core. SAR analysis and molecular modeling reveal that the essential pharmacophore of these tannins resides in the corilagin moiety. The outer complex carboxylic acid moieties appear to act only as auxopharmacore.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-1999-13960