Interleukin-18 and interleukin-1β : Two cytokine substrates for ICE (Caspase-1)

This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-inducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well a...

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Veröffentlicht in:	Journal of clinical immunology 1999, Vol.19 (1), p.1-11
Hauptverfasser:	FANTUZZI, G, DINARELLO, C. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Caspase 1 - metabolism Caspase-1 Enzymes Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IL-1β Immunobiology Interleukin 18 Interleukin 18 receptors Interleukin-1 - metabolism Interleukin-18 - metabolism Lymphokines, interleukins ( function, expression) Macrophages - immunology Mice Molecular Sequence Data Monocytes - immunology Regulatory factors and their cellular receptors Signal Transduction γ-Interferon
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Beschreibung
Zusammenfassung:	This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-inducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well as the importance of alternative cleavage enzymes. The topic of this review also concerns the biology of IL-18. The regulation of IL-18 production, the IL-18 receptor complex, and the biological effects of this novel cytokine are described.
ISSN:	0271-9142 1573-2592
DOI:	10.1023/A:1020506300324