Norpregnane Glycosides from a Thai Soft Coral, Scleronephthya pallida

Two new norpregnane glycosides, 19-norpregna-1,3,5(10),20-tetraen-3-O-α-fucopyranoside (3) and 19-norpregna-1,3,5(10),20-tetraen-3-O-β-arabinopyranoside (4), were isolated from the soft coral Scleronephthya pallida, along with two known steroids, pregna-1,20-dien-3-one (1) and 19-norpregna-1,3,5(10)...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1999-02, Vol.62 (2), p.318-320
Hauptverfasser:	Kittakoop, Prasat, Suttisri, Rutt, Chaichantipyuth, Chaiyo, Vethchagarun, Siripen, Suwanborirux, Khanit
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals antimalarial properties Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Biological and medical sciences Carbohydrate Sequence chemical composition chemical structure Cnidaria - chemistry corals cytotoxic compounds Fundamental and applied biological sciences. Psychology glycosides Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Marine norpregnane glycosides Norpregnanes - chemistry Norpregnanes - isolation & purification Norpregnanes - pharmacology Other biological molecules Plasmodium falciparum - drug effects pregnanes Scleronephthya pallida spectral analysis Spectrum Analysis steroids Terpenes, steroids. Hormones
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Zusammenfassung:	Two new norpregnane glycosides, 19-norpregna-1,3,5(10),20-tetraen-3-O-α-fucopyranoside (3) and 19-norpregna-1,3,5(10),20-tetraen-3-O-β-arabinopyranoside (4), were isolated from the soft coral Scleronephthya pallida, along with two known steroids, pregna-1,20-dien-3-one (1) and 19-norpregna-1,3,5(10),20-tetraen-3-ol (2). 19-Norpregna-1,3,5(10),20-tetraen-3-O-α-fucopyranoside (3) exhibits moderate antimalarial and cytotoxic activities. The chemical structures of 1 − 4 were elucidated from spectroscopic data.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np980273w