Antiangiogenic Activity of Tumor Necrosis Factor-α Production Regulators Derived from Thalidomide
Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived fromthalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenes...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1999/02/15, Vol.22(2), pp.224-226 |
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| container_end_page | 226 |
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| container_issue | 2 |
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| container_title | Biological & pharmaceutical bulletin |
| container_volume | 22 |
| creator | SHIMAZAWA, Rumiko MIYACHI, Hiroyuki TAKAYAMA, Hisae KURODA, Kensei KATO, Fuminori KATO, Masanari HASHIMOTO, Yuichi |
| description | Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived fromthalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay. |
| doi_str_mv | 10.1248/bpb.22.224 |
| format | Article |
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Drug treatments</subject><subject>phthalimide</subject><subject>Stereoisomerism</subject><subject>thalidomide</subject><subject>Thalidomide - analogs & derivatives</subject><subject>Thalidomide - chemistry</subject><subject>Thalidomide - pharmacology</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>tumor necrosis factor-α</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0M1q3DAQAGBREppNmksfoOhQeig4lWTZso7LpkkDISllczZjabxRsK2tZC_ksfIifaZqs5sfGCSh-ZiRhpDPnJ1xIasfzbo5EyKF_EBmPJcqKwQvDsiMaV5lJS-qI3Ic4wNjTDGRfyRHPJ2UlHpGmvkwOhhWzq9wcIbOzeg2bnykvqXLqfeB3qAJPrpIL8CMPmT_nujv4O2UoB_oH1xNHaT7SM8xuA1a2gbf0-U9dM763ln8RA5b6CKe7vcTcnfxc7n4lV3fXl4t5teZKbQes0qVqkXOGsa55MpKUIwhq3SFULRQgmDS8rKwnOtGWZTClAywyNGIvG2K_IR829VdB_93wjjWvYsGuw4G9FOsS10KrrVK8PsObj8WA7b1OrgewmPNWb2daJ0mWguRQib8ZV91anq07-huhAl83QOIBro2wGBcfHMql0KIxBY79hBHWOFrHsLoTIfblulx-XPbl0W-Zs09hBqH_D9taJcm</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>SHIMAZAWA, Rumiko</creator><creator>MIYACHI, Hiroyuki</creator><creator>TAKAYAMA, Hisae</creator><creator>KURODA, Kensei</creator><creator>KATO, Fuminori</creator><creator>KATO, Masanari</creator><creator>HASHIMOTO, Yuichi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Antiangiogenic Activity of Tumor Necrosis Factor-α Production Regulators Derived from Thalidomide</title><author>SHIMAZAWA, Rumiko ; MIYACHI, Hiroyuki ; TAKAYAMA, Hisae ; KURODA, Kensei ; KATO, Fuminori ; KATO, Masanari ; HASHIMOTO, Yuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c599t-8767fe10b011417d4a700e0898ea5fa6a204d165d119b7de42c60ae53ec23fb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>antiangiogenesis</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Fibroblast Growth Factor 2 - pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neovascularization, Pathologic - prevention & control</topic><topic>Pharmacology. Drug treatments</topic><topic>phthalimide</topic><topic>Stereoisomerism</topic><topic>thalidomide</topic><topic>Thalidomide - analogs & derivatives</topic><topic>Thalidomide - chemistry</topic><topic>Thalidomide - pharmacology</topic><topic>Tumor Cells, Cultured</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIMAZAWA, Rumiko</creatorcontrib><creatorcontrib>MIYACHI, Hiroyuki</creatorcontrib><creatorcontrib>TAKAYAMA, Hisae</creatorcontrib><creatorcontrib>KURODA, Kensei</creatorcontrib><creatorcontrib>KATO, Fuminori</creatorcontrib><creatorcontrib>KATO, Masanari</creatorcontrib><creatorcontrib>HASHIMOTO, Yuichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIMAZAWA, Rumiko</au><au>MIYACHI, Hiroyuki</au><au>TAKAYAMA, Hisae</au><au>KURODA, Kensei</au><au>KATO, Fuminori</au><au>KATO, Masanari</au><au>HASHIMOTO, Yuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiangiogenic Activity of Tumor Necrosis Factor-α Production Regulators Derived from Thalidomide</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1999</date><risdate>1999</risdate><volume>22</volume><issue>2</issue><spage>224</spage><epage>226</epage><pages>224-226</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived fromthalidomide. 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| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1999/02/15, Vol.22(2), pp.224-226 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69621997 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | AIDS/HIV Animals antiangiogenesis Antineoplastic agents Biological and medical sciences Chemotherapy Fibroblast Growth Factor 2 - pharmacology Humans Medical sciences Mice Mice, Inbred BALB C Neovascularization, Pathologic - prevention & control Pharmacology. Drug treatments phthalimide Stereoisomerism thalidomide Thalidomide - analogs & derivatives Thalidomide - chemistry Thalidomide - pharmacology Tumor Cells, Cultured Tumor Necrosis Factor-alpha - biosynthesis tumor necrosis factor-α |
| title | Antiangiogenic Activity of Tumor Necrosis Factor-α Production Regulators Derived from Thalidomide |
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