Antiangiogenic Activity of Tumor Necrosis Factor-α Production Regulators Derived from Thalidomide

Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived fromthalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenes...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1999/02/15, Vol.22(2), pp.224-226
Hauptverfasser:	SHIMAZAWA, Rumiko, MIYACHI, Hiroyuki, TAKAYAMA, Hisae, KURODA, Kensei, KATO, Fuminori, KATO, Masanari, HASHIMOTO, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals antiangiogenesis Antineoplastic agents Biological and medical sciences Chemotherapy Fibroblast Growth Factor 2 - pharmacology Humans Medical sciences Mice Mice, Inbred BALB C Neovascularization, Pathologic - prevention & control Pharmacology. Drug treatments phthalimide Stereoisomerism thalidomide Thalidomide - analogs & derivatives Thalidomide - chemistry Thalidomide - pharmacology Tumor Cells, Cultured Tumor Necrosis Factor-alpha - biosynthesis tumor necrosis factor-α
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Beschreibung
Zusammenfassung:	Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived fromthalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.22.224