Sideroxylonal C, a New Inhibitor of Human Plasminogen Activator Inhibitor Type-1, from the Flowers of Eucalyptus albens

Sideroxylonal C, a New Inhibitor of Human Plasminogen Activator Inhibitor Type-1, from the Flowers of Eucalyptus albens

Sideroxylonal C (3), a new phloroglucinol dimer, was isolated from the flowers of Eucalyptus albens through bioassay-guided fractionation. The structure elucidation was based on 1D and 2D NMR experiments, MS analysis, and comparison with sideroxylonals A (1) and B (2). Sideroxylonal C inhibited huma...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 1999-02, Vol.62 (2), p.324-326
Hauptverfasser: Neve, Juliette, de Almeida Leone, Priscila, Carroll, Anthony R, Moni, Roger W, Paczkowski, Natalii J, Pierens, Greg, Björquist, Petter, Deinum, Johanna, Ehnebom, Johanna, Inghardt, Tord, Guymer, Gordon, Grimshaw, Paul, Quinn, Ronald J
Format: Artikel
Sprache:eng
Schlagworte:
Benzofurans - chemistry
Benzofurans - isolation & purification
Benzofurans - pharmacology
Biological and medical sciences
chemical constituents of plants
chemical structure
Eucalyptus
Eucalyptus - chemistry
fibrinolysis
flowers
General pharmacology
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phloroglucinol - analogs & derivatives
Plants, Medicinal
plasminogen activator
Plasminogen Activator Inhibitor 1 - chemistry
spectral analysis
Surface Plasmon Resonance
thrombosis
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Beschreibung
Zusammenfassung:Sideroxylonal C (3), a new phloroglucinol dimer, was isolated from the flowers of Eucalyptus albens through bioassay-guided fractionation. The structure elucidation was based on 1D and 2D NMR experiments, MS analysis, and comparison with sideroxylonals A (1) and B (2). Sideroxylonal C inhibited human plasminogen activator inhibitor type-1 at 4.7 μM without any significant effect on human tissue plasminogen activator.
ISSN:0163-3864
1520-6025
DOI:10.1021/np980286+