Diffusion Tensor Imaging in Familial Spastic Paraplegia with Mental Impairment and Thin Corpus Callosum

We investigated 2 Japanese siblings with a complicated form of familial spastic paraplegia. Cranial magnetic resonance (MR) imaging revealed marked thinning of the corpus callosum. Diffusion tensor imaging (DTI) showed microstructural changes in the thalamus, basal ganglia, and cerebral white matter...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Magnetic Resonance in Medical Sciences 2008, Vol.7(3), pp.163-167
Hauptverfasser:	OTA, Miho, SATO, Noriko, SAITOH, Yuji, ENDO, Fumito, MURATA, Miho, ASADA, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Cognition Disorders - diagnosis Cognition Disorders - genetics Corpus Callosum - pathology Diffusion Magnetic Resonance Imaging - methods diffusion tensor imaging familial spastic paraplegia fractional anisotropy Humans Male mean diffusivity Paraplegia - congenital Paraplegia - diagnosis Reproducibility of Results Sensitivity and Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We investigated 2 Japanese siblings with a complicated form of familial spastic paraplegia. Cranial magnetic resonance (MR) imaging revealed marked thinning of the corpus callosum. Diffusion tensor imaging (DTI) showed microstructural changes in the thalamus, basal ganglia, and cerebral white matter, and single photon emission computed tomography (SPECT) using 99mTc-ethylcysteinate dimer showed very similar findings. DTI and SPECT effectively revealed global changes not revealed by conventional MR imaging.
ISSN:	1347-3182 1880-2206
DOI:	10.2463/mrms.7.163