Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture

After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell,...

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Veröffentlicht in:Applied microbiology and biotechnology 2008-10, Vol.80 (6), p.1087-1093
Hauptverfasser: Yoon, Taek Joon, Yu, Kwang-Won, Shin, Kwang-Soon, Suh, Hyung Joo
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Sprache:eng
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Zusammenfassung:After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 μg/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-008-1607-y