Pancreatic Stellate Cells and Pancreatic Cancer Cells : An Unholy Alliance

Pancreatic cancer--a tumor displaying a particularly abundant stromal reaction--is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression. Character...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-10, Vol.68 (19), p.7707-7710
Hauptverfasser:	VONLAUFEN, Alain, PHILLIPS, Phoebe A, ZHIHONG XU, GOLDSTEIN, David, PIROLA, Romano C, WILSON, Jeremy S, APTE, Minoti V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Proliferation Disease Progression Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Models, Biological Pancreas - cytology Pancreas - physiology Pancreatic Neoplasms - etiology Pancreatic Neoplasms - pathology Pharmacology. Drug treatments Stromal Cells - physiology Tumors
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Zusammenfassung:	Pancreatic cancer--a tumor displaying a particularly abundant stromal reaction--is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression. Characterization of the mechanisms mediating PSC-cancer interactions will lead to the development of much needed alternative therapeutic approaches to improve disease outcome.
ISSN:	0008-5472 1538-7445
DOI:	10.1158/0008-5472.CAN-08-1132