B Cell Response After MMTV Infection: Extrafollicular Plasmablasts Represent the Main Infected Population and Can Transmit Viral Infection
The immune response to mouse mammary tumor virus (MMTV) relies on the presentation of an MMTV-encoded superantigen by infected B cells to superantigen-specific T cells. The initial extrafollicular B cell differentiation involved the generation of B cells expressing low levels of B220. These B220low...
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| Veröffentlicht in: | The Journal of immunology (1950) 1999-03, Vol.162 (5), p.2538-2545 |
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| container_issue | 5 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 162 |
| creator | Ardavin, Carlos Martin, Pilar Ferrero, Isabel Azcoitia, Inigo Anjuere, Fabienne Diggelmann, Heidi Luthi, Frederic Luther, Sanjiv Acha-Orbea, Hans |
| description | The immune response to mouse mammary tumor virus (MMTV) relies on the presentation of an MMTV-encoded superantigen by infected B cells to superantigen-specific T cells. The initial extrafollicular B cell differentiation involved the generation of B cells expressing low levels of B220. These B220low B cells corresponded to plasmablasts that expressed high levels of CD43 and syndecan-1 and were CD62 ligand- and IgD-. Viral DNA was detected nearly exclusively in these B220low B cells by PCR, and retroviral type-A particles were observed in their cytoplasm by electron microscopy. An MMTV transmission to the offspring was also achieved after transfer of B220low CD62 ligand- CD43+ plasmablasts into noninfected females. These data suggest that B220low plasmablasts, representing the bulk of infected B cells, are capable of sustaining viral replication and may be involved in the transmission of MMTV. |
| doi_str_mv | 10.4049/jimmunol.162.5.2538 |
| format | Article |
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The initial extrafollicular B cell differentiation involved the generation of B cells expressing low levels of B220. These B220low B cells corresponded to plasmablasts that expressed high levels of CD43 and syndecan-1 and were CD62 ligand- and IgD-. Viral DNA was detected nearly exclusively in these B220low B cells by PCR, and retroviral type-A particles were observed in their cytoplasm by electron microscopy. An MMTV transmission to the offspring was also achieved after transfer of B220low CD62 ligand- CD43+ plasmablasts into noninfected females. These data suggest that B220low plasmablasts, representing the bulk of infected B cells, are capable of sustaining viral replication and may be involved in the transmission of MMTV.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.162.5.2538</identifier><identifier>PMID: 10072493</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Animals ; Antigens, CD ; B-Lymphocytes - immunology ; Female ; L-Selectin - analysis ; Leukocyte Common Antigens - analysis ; Leukosialin ; Mammary Tumor Virus, Mouse - immunology ; Mice ; Mice, Inbred BALB C ; Mouse mammary tumor virus ; Retroviridae Infections - immunology ; Retroviridae Infections - pathology ; Retroviridae Infections - transmission ; Sialoglycoproteins - analysis ; Tumor Virus Infections - immunology ; Tumor Virus Infections - pathology ; Tumor Virus Infections - transmission</subject><ispartof>The Journal of immunology (1950), 1999-03, Vol.162 (5), p.2538-2545</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-38e677793c34675ecfbd39a8ddd785b851372b824412b9e9115394b74d118ee13</citedby><cites>FETCH-LOGICAL-c409t-38e677793c34675ecfbd39a8ddd785b851372b824412b9e9115394b74d118ee13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10072493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ardavin, Carlos</creatorcontrib><creatorcontrib>Martin, Pilar</creatorcontrib><creatorcontrib>Ferrero, Isabel</creatorcontrib><creatorcontrib>Azcoitia, Inigo</creatorcontrib><creatorcontrib>Anjuere, Fabienne</creatorcontrib><creatorcontrib>Diggelmann, Heidi</creatorcontrib><creatorcontrib>Luthi, Frederic</creatorcontrib><creatorcontrib>Luther, Sanjiv</creatorcontrib><creatorcontrib>Acha-Orbea, Hans</creatorcontrib><title>B Cell Response After MMTV Infection: Extrafollicular Plasmablasts Represent the Main Infected Population and Can Transmit Viral Infection</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>The immune response to mouse mammary tumor virus (MMTV) relies on the presentation of an MMTV-encoded superantigen by infected B cells to superantigen-specific T cells. The initial extrafollicular B cell differentiation involved the generation of B cells expressing low levels of B220. These B220low B cells corresponded to plasmablasts that expressed high levels of CD43 and syndecan-1 and were CD62 ligand- and IgD-. Viral DNA was detected nearly exclusively in these B220low B cells by PCR, and retroviral type-A particles were observed in their cytoplasm by electron microscopy. An MMTV transmission to the offspring was also achieved after transfer of B220low CD62 ligand- CD43+ plasmablasts into noninfected females. These data suggest that B220low plasmablasts, representing the bulk of infected B cells, are capable of sustaining viral replication and may be involved in the transmission of MMTV.</description><subject>Animals</subject><subject>Antigens, CD</subject><subject>B-Lymphocytes - immunology</subject><subject>Female</subject><subject>L-Selectin - analysis</subject><subject>Leukocyte Common Antigens - analysis</subject><subject>Leukosialin</subject><subject>Mammary Tumor Virus, Mouse - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mouse mammary tumor virus</subject><subject>Retroviridae Infections - immunology</subject><subject>Retroviridae Infections - pathology</subject><subject>Retroviridae Infections - transmission</subject><subject>Sialoglycoproteins - analysis</subject><subject>Tumor Virus Infections - immunology</subject><subject>Tumor Virus Infections - pathology</subject><subject>Tumor Virus Infections - transmission</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAURi1ERaeFJ0BCXsEqgx3_xezaUQuVOqJCQ7eWk9wwrhwn2ImGvkKfGo9mEN11c-_mnO9K90PoPSVLTrj-_OD6fg6DX1JZLsWyFKx6hRZUCFJISeRrtCCkLAuqpDpFZyk9EEIkKfkbdEoJUSXXbIGeLvEKvMc_II1DSIAvugkiXq839_gmdNBMbghf8NWfKdpu8N41s7cR33mbelvnOaXsjhEShAlPW8Br68JRhRbfDWMW9iHYhhavbMCbaEPq3YTvXbT-_5W36KSzPsG74z5HP6-vNqtvxe33rzeri9ui4URPBatAKqU0axiXSkDT1S3TtmrbVlWirgRlqqyrknNa1ho0pYJpXiveUloBUHaOPh5yxzj8niFNpnepyU-wAYY5GaklFZUiL4JUUa04lRlkB7CJQ0oROjNG19v4aCgx-67Mv65M7soIs-8qWx-O8XPdQ_vMOZSTgU8HYOt-bXcugsk_9z7j1Ox2u2dRfwHxt6BC</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Ardavin, Carlos</creator><creator>Martin, Pilar</creator><creator>Ferrero, Isabel</creator><creator>Azcoitia, Inigo</creator><creator>Anjuere, Fabienne</creator><creator>Diggelmann, Heidi</creator><creator>Luthi, Frederic</creator><creator>Luther, Sanjiv</creator><creator>Acha-Orbea, Hans</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>B Cell Response After MMTV Infection: Extrafollicular Plasmablasts Represent the Main Infected Population and Can Transmit Viral Infection</title><author>Ardavin, Carlos ; Martin, Pilar ; Ferrero, Isabel ; Azcoitia, Inigo ; Anjuere, Fabienne ; Diggelmann, Heidi ; Luthi, Frederic ; Luther, Sanjiv ; Acha-Orbea, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-38e677793c34675ecfbd39a8ddd785b851372b824412b9e9115394b74d118ee13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Antigens, CD</topic><topic>B-Lymphocytes - immunology</topic><topic>Female</topic><topic>L-Selectin - analysis</topic><topic>Leukocyte Common Antigens - analysis</topic><topic>Leukosialin</topic><topic>Mammary Tumor Virus, Mouse - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mouse mammary tumor virus</topic><topic>Retroviridae Infections - immunology</topic><topic>Retroviridae Infections - pathology</topic><topic>Retroviridae Infections - transmission</topic><topic>Sialoglycoproteins - analysis</topic><topic>Tumor Virus Infections - immunology</topic><topic>Tumor Virus Infections - pathology</topic><topic>Tumor Virus Infections - transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ardavin, Carlos</creatorcontrib><creatorcontrib>Martin, Pilar</creatorcontrib><creatorcontrib>Ferrero, Isabel</creatorcontrib><creatorcontrib>Azcoitia, Inigo</creatorcontrib><creatorcontrib>Anjuere, Fabienne</creatorcontrib><creatorcontrib>Diggelmann, Heidi</creatorcontrib><creatorcontrib>Luthi, Frederic</creatorcontrib><creatorcontrib>Luther, Sanjiv</creatorcontrib><creatorcontrib>Acha-Orbea, Hans</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ardavin, Carlos</au><au>Martin, Pilar</au><au>Ferrero, Isabel</au><au>Azcoitia, Inigo</au><au>Anjuere, Fabienne</au><au>Diggelmann, Heidi</au><au>Luthi, Frederic</au><au>Luther, Sanjiv</au><au>Acha-Orbea, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B Cell Response After MMTV Infection: Extrafollicular Plasmablasts Represent the Main Infected Population and Can Transmit Viral Infection</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>162</volume><issue>5</issue><spage>2538</spage><epage>2545</epage><pages>2538-2545</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>The immune response to mouse mammary tumor virus (MMTV) relies on the presentation of an MMTV-encoded superantigen by infected B cells to superantigen-specific T cells. The initial extrafollicular B cell differentiation involved the generation of B cells expressing low levels of B220. These B220low B cells corresponded to plasmablasts that expressed high levels of CD43 and syndecan-1 and were CD62 ligand- and IgD-. Viral DNA was detected nearly exclusively in these B220low B cells by PCR, and retroviral type-A particles were observed in their cytoplasm by electron microscopy. An MMTV transmission to the offspring was also achieved after transfer of B220low CD62 ligand- CD43+ plasmablasts into noninfected females. These data suggest that B220low plasmablasts, representing the bulk of infected B cells, are capable of sustaining viral replication and may be involved in the transmission of MMTV.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>10072493</pmid><doi>10.4049/jimmunol.162.5.2538</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antigens, CD B-Lymphocytes - immunology Female L-Selectin - analysis Leukocyte Common Antigens - analysis Leukosialin Mammary Tumor Virus, Mouse - immunology Mice Mice, Inbred BALB C Mouse mammary tumor virus Retroviridae Infections - immunology Retroviridae Infections - pathology Retroviridae Infections - transmission Sialoglycoproteins - analysis Tumor Virus Infections - immunology Tumor Virus Infections - pathology Tumor Virus Infections - transmission |
| title | B Cell Response After MMTV Infection: Extrafollicular Plasmablasts Represent the Main Infected Population and Can Transmit Viral Infection |
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