Ras caught in another affair: the exchange factors for Ral

The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic...

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Veröffentlicht in:	Current opinion in genetics & development 1999-02, Vol.9 (1), p.112-117
Hauptverfasser:	Wolthuis, Rob MF, Bos, Johannes L
Format:	Artikel
Sprache:	eng
Schlagworte:	Enzyme Activation GTP Phosphohydrolases - metabolism GTP-Binding Proteins - metabolism Guanine Nucleotide Exchange Factors Guanosine Triphosphate - metabolism Humans Proteins - metabolism ral GTP-Binding Proteins rap GTP-Binding Proteins ras Guanine Nucleotide Exchange Factors ras Proteins - physiology
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Zusammenfassung:	The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.
ISSN:	0959-437X 1879-0380
DOI:	10.1016/S0959-437X(99)80016-1