Quantitative assessment of the degree of villous atrophy in patients with coeliac disease

Background:Endoscopy and biopsy are used to diagnose coeliac disease. There are, however, observer-dependent interpretations of the degree of villous atrophy in biopsies. A pilot study using quantitative image-processing procedures was performed to quantify the degree of villous atrophy in patients...

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Veröffentlicht in:Journal of clinical pathology 2008-10, Vol.61 (10), p.1089-1092
Hauptverfasser: Ciaccio, E J, Bhagat, G, Naiyer, A J, Hernandez, L, Green, P H R
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Sprache:eng
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Zusammenfassung:Background:Endoscopy and biopsy are used to diagnose coeliac disease. There are, however, observer-dependent interpretations of the degree of villous atrophy in biopsies. A pilot study using quantitative image-processing procedures was performed to quantify the degree of villous atrophy in patients with coeliac disease.Method:The degree of villous atrophy in duodenal biopsy images was quantified by calculating the ratio of villous edge-to-piecewise arc length (E/P ratio), and this value was compared with the blinded assessment of Marsh score for degree of villous atrophy.Results:Mean E/P ratios for n = 31 biopsy images, 2.76 (SD 0.44) (Marsh IIIa), 1.91 (0.50) (Marsh IIIb) and 1.18 (0.22) (Marsh IIIc), were significantly different (p = 0.006). Based on non-parametric testing, the E/P ratios were inversely correlated with Marsh scores (Spearman coefficient ρ = −0.798, Kendall τ = −0.681; p
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2008.058669