Synthesis of 2-Cyclohexenone Derivatives via Gold(I)-Catalyzed Hydrative Cyclization of 1,6-Diynes

The gold(I) complex (MeAuPPh3) was found to be a highly effective catalyst for the hydrative cyclization of 1,6-diynes to form the corresponding 3-methyl hex-2-enone derivatives with good to excellent yield. The proposed mechanism is described.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2008-10, Vol.73 (19), p.7811-7813
Hauptverfasser:	Zhang, Chen, Cui, Dong-Mei, Yao, Li-Ying, Wang, Bi-Song, Hu, Yong-Zhou, Hayashi, Teruyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds Alicyclic compounds, terpenoids, prostaglandins, steroids Catalysis Catalysts: preparations and properties Chemistry Cyclohexenes - chemical synthesis Diynes - chemistry Exact sciences and technology General and physical chemistry Gold - chemistry Ketones Kinetics and mechanisms Organic chemistry Preparations and properties Reactivity and mechanisms Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Beschreibung
Zusammenfassung:	The gold(I) complex (MeAuPPh3) was found to be a highly effective catalyst for the hydrative cyclization of 1,6-diynes to form the corresponding 3-methyl hex-2-enone derivatives with good to excellent yield. The proposed mechanism is described.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo800974x